Evidence map›Paper›PMID 40793769›Full record

ArticleApplied and environmental microbiology2025

The HOG signal pathway contributes to survival strategies of the piezo-tolerant fungus

Guangzhao Hu, Maosheng Zhong, Changhao Zhang, Hongfu Lai, Eva Breyer, Jiasong Fang, Xi Yu

Abstract read
In one paragraph

Article in Applied and environmental microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Environmental Adaptation Strategies of Deep-Sea Fungi.Journal of fungi (Basel, Switzerland) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Guangzhao Hu *Shanghai Engineering Research Center of Hadal Science and Technology, College of Oceanography and Ecological Science, Shanghai Ocean University, Shanghai, China.ORCID 0000-0002-5019-9391
Maosheng Zhong *Shanghai Engineering Research Center of Hadal Science and Technology, College of Oceanography and Ecological Science, Shanghai Ocean University, Shanghai, China.
Changhao ZhangShanghai Engineering Research Center of Hadal Science and Technology, College of Oceanography and Ecological Science, Shanghai Ocean University, Shanghai, China.
Hongfu LaiShanghai Engineering Research Center of Hadal Science and Technology, College of Oceanography and Ecological Science, Shanghai Ocean University, Shanghai, China.
Eva BreyerShanghai Engineering Research Center of Hadal Science and Technology, College of Oceanography and Ecological Science, Shanghai Ocean University, Shanghai, China.
Jiasong FangShanghai Engineering Research Center of Hadal Science and Technology, College of Oceanography and Ecological Science, Shanghai Ocean University, Shanghai, China.
Xi YuShanghai Engineering Research Center of Hadal Science and Technology, College of Oceanography and Ecological Science, Shanghai Ocean University, Shanghai, China.ORCID 0000-0003-4243-6016

Funding

National Natural Science Foundation of China 42476091,9225133Shanghai Municipal Education Commission 2023ZKZD53
6 · The paper itself

Abstract

The hadal zone, one of Earth's most extreme ecosystems, harbors diverse and unique microbial communities adapted to its harsh environmental conditions, including high hydrostatic pressure (HHP) and low temperatures. Within these communities, deep-sea fungi play a critical role in geochemical cycling and marine ecosystem functioning; however, research on their cultivable strains and adaptation mechanism remains scarce. In this study, the piezo-tolerant fungus IMPORTANCE: Research on the genomes and gene functions of hadal zone fungi is crucial for understanding life's adaptation to extreme environments. However, current studies on constructing genetic operation systems for marine-derived filamentous fungi are scarce, and research on HHP environments in related fields is virtually non-existent. Our study highlights the critical role of the HOG-mediated pathway in regulating stress responses and metabolic processes in extremophiles, a regulatory mechanism that had not been previously investigated under HHP conditions. Notably, the whole-genome annotation of the hadal fungus

Indexed as

AspergillusFungal ProteinsGeologic SedimentsSignal TransductionAdaptation, PhysiologicalExtreme EnvironmentsHydrostatic PressureFungal Proteinsgene knockoutgenome analysishadal fungiHHPHOG

Identifiers

PMID40793769
PMCPMC12442359

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.