ReviewRegenerative medicine2025
Migrasomes: a promising extracellular vesicle-like novel organelle for bone regeneration.
Review in Regenerative medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Role of Extracellular Vesicles in Musculoskeletal Diseases.Journal of extracellular vesicles · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone regeneration represents a key objective in bone tissue engineering and involves a series of coordinated biological processes, including immunomodulation, neuroregulation, angiogenesis, and osteogenesis. Recent studies have underscored the therapeutic potential of extracellular vesicles (EVs) in promoting osteogenesis and facilitating the repair of bone defects, supporting their application as a promising cell-free strategy in regenerative medicine. Migrasomes, vesicle-like organelles anchored to retraction fibers and first identified in 2015, have emerged as key mediators in intercellular communication, lateral transfer of mRNA and proteins, and mitochondrial homeostasis. Through cell-free treatment, these functions support the activity and regenerative ability of stem cells during bone repair. This review provides an updated overview of migrasome-related research, emphasizing their roles in molecular delivery and regulation during bone regeneration. Moreover, the potential of migrasomes as innovative tools for bone tissue engineering is discussed, along with prospective strategies to enhance their utility through advances in understanding their biogenesis and cargo sorting. Despite their known biological functions, the therapeutic applications of migrasomes in bone regeneration remain largely unexplored, highlighting the need for further investigation in this emerging field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.