Evidence map›Paper›PMID 40792599›Full record

Trial reportJournal of the American Heart Association2025

Revisiting the Effect of Udenafil on Exercise Performance in Patients With Fontan Circulation: Results of a Post Hoc Analysis of the FUEL Trial.

David J Goldberg, Victor Zak, Chenwei Hu, Adam M Lubert, Rahul H Rathod, Daniel J Penny, Robert Whitehill, Kurt R Schumacher, Salil Ginde, Michelle Ploutz and 25 more

Abstract readClinical Trial, Phase IIIMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

David J GoldbergDivision of Cardiology The Children's Hospital of Philadelphia, Perelman School of Medicine Philadelphia PA USA.ORCID 0000-0002-4194-2067
Victor ZakCarelon Research Newton MA USA.
Chenwei HuCarelon Research Newton MA USA.
Adam M LubertDepartment of Pediatrics, Cincinnati Children's Hospital Heart Institute University of Cincinnati College of Medicine Cincinnati OH USA.ORCID 0000-0001-6401-9980
Rahul H RathodDepartment of Cardiology, Boston Children's Hospital, Department of Pediatrics Harvard Medical School Boston MA USA.ORCID 0000-0002-7149-5421
Daniel J PennyDivision of Cardiology, Texas Children's Hospital Baylor College of Medicine Houston TX USA.
Robert WhitehillChildren's Healthcare of Atlanta Emory University School of Medicine Atlanta GA USA.ORCID 0000-0002-3810-7132
Kurt R SchumacherDivision of Cardiology C.S. Mott Children's Hospital Ann Arbor MI USA.ORCID 0000-0001-8659-736X
Salil GindeDivision of Cardiology Medical College of Wisconsin, Children's Wisconsin Milwaukee WI USA.ORCID 0000-0001-9218-1993
Michelle PloutzDivision of Pediatric Cardiology University of Utah, Primary Children's Hospital Salt Lake City UT USA.
Gi Beom KimSeoul National University School of Medicine Seoul National University Children's Hospital Seoul South Korea.ORCID 0000-0002-7880-280X
Todd T NowlenHeart Center Phoenix Children's Hospital Phoenix AZ USA.ORCID 0000-0001-9615-6138
Michael V DiMariaDepartment of Pediatrics, Children's Hospital Colorado University of Colorado School of Medicine Aurora CO USA.ORCID 0000-0003-0346-8517
Benjamin P FrischhertzDivision of Cardiology Vanderbilt University Medical Center, Division of Cardiovascular Medicine Nashville TN USA.ORCID 0000-0003-2949-6073
Jonathan B WagnerDivisions of Cardiology and Clinical Pharmacology Children's Mercy Kansas City Kansas City MO USA.ORCID 0000-0001-7690-6798
Kimberly E McHughDivision of Pediatric Cardiology Medical University of South Carolina Charleston SC USA.
Brian W McCrindleThe Labatt Family Heart Centre, The Hospital for Sick Children, Department of Pediatrics University of Toronto Toronto ON USA.ORCID 0000-0001-6485-6551
Mark J CartoskiNemours Cardiac Center Nemours/Alfred I. DuPont Hospital for Children Wilmington DE USA.
Jon DetterichDivision of Cardiology Children's Hospital Los Angeles Los Angeles CA USA.ORCID 0000-0002-2086-9569
Anji T YetmanChildren's Hospital and Medical Center University of Nebraska Omaha NE USA.ORCID 0000-0001-6853-578X
Anitha S JohnDivision of Cardiology Children's National Hospital Washington DC USA.
Marc E RichmondDivision of Pediatric Cardiology, Morgan Stanley Children's Hospital Columbia University Medical Center New York NY USA.ORCID 0000-0001-5491-8085
Matthew FilesDivision of Pediatric Cardiology University of Washington School of Medicine, Seattle Children's Hospital Seattle WA USA.ORCID 0000-0002-9506-5477
R Mark PayneDivision of Cardiology, Riley Hospital for Children Indiana University School of Medicine Indianapolis IN USA.ORCID 0000-0002-6232-3628
Andrew S MackieDivision of Cardiology Stollery Children's Hospital Edmonton Alberta Canada.ORCID 0000-0001-6126-1130
Christopher K DavisDivision of Cardiology Rady Children's Hospital San Diego, University of California San Diego San Diego CA USA.
William B OrrDivision of Pediatric Cardiology Washington University School of Medicine St. Louis MO USA.
Ruchira GargPediatric Congenital Heart Program at Guerin Children's and Smidt Heart Hospital Cedars-Sinai Medical Center Los Angeles CA USA.ORCID 0000-0002-7258-6480
Kevin D HillDuke Children's Pediatric and Congenital Heart Center Durham NC USA.ORCID 0000-0003-4451-3580
Jennifer S YauckDivision of Cardiology Medical College of Wisconsin, Children's Wisconsin Milwaukee WI USA.
Michael G McBrideDivision of Cardiology The Children's Hospital of Philadelphia, Perelman School of Medicine Philadelphia PA USA.
James YeagerMezzion Pharm Co. Ltd. For Lee NJ USA.
Gail D PearsonDivision of Cardiovascular Sciences National Heart, Lung, and Blood Institute, NIH Bethesda MD USA.
Stephen M ParidonDivision of Cardiology The Children's Hospital of Philadelphia, Perelman School of Medicine Philadelphia PA USA.ORCID 0000-0003-3330-0598
Bryan H GoldsteinHeart Institute, UPMC Children's Hospital of Pittsburgh, Department of Pediatrics University of Pittsburgh School of Medicine Pittsburgh PA USA.ORCID 0000-0001-8508-9523

Funding

MIS-C Program: Data Coordinating Center for the Pediatric Heart Network MIS-C ProgramU24HL135691 · NHLBI · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI MILLER, JULIE ELAINE, TRACHTENBERG, FELICIA LYNN · 2017 to 2024
$37.9M
Pediatric Heart Network Clinical Research Centers - Boston Children's HospitalUG1HL135685 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI NEWBURGER, JANE W., TRIEDMAN, JOHN K · 2017 to 2023
$2.7M
Pediatric Heart Network Children's Hospital of PhiladelphiaUG1HL135683 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI GAYNOR, JAMES WILLIAM, GOLDBERG, DAVID J · 2017 to 2023
$2.6M
Baylor/Texas Children's Hospital Pediatric Heart NetworkUG1HL135666 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI HEINLE, JEFFREY STEPHEN, PENNY, DANIEL J · 2017 to 2023
$2.4M
Pediatric Heart Network Prairieland ConsortiumUG1HL135678 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI CNOTA, JAMES, PAYNE, RONALD MARK · 2017 to 2023
$2.4M
Pediatric Heart Network Regents of the University of MichiganUG1HL135665 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GOLDBERG, CAREN S, OHYE, RICHARD G · 2017 to 2023
$2.4M
Pediatric Heart Network - Utah CenterUG1HL135646 · NHLBI · UNIVERSITY OF UTAH · PI MINICH, L. LUANN, WILLIAMS, RICHARD VINCENT · 2017 to 2023
$2.3M
Pediatric Heart Network Clinical Research Center - Medical University of South CarolinaUG1HL135689 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ATZ, ANDREW M, GRAHAM, ERIC M. · 2017 to 2023
$2.3M
Pediatric Heart Network Emory UniversityUG1HL135682 · NHLBI · EMORY UNIVERSITY · PI BOOK, WENDY M., KOCHILAS, LAZAROS K. · 2017 to 2023
$2.2M
Pediatric Heart Network - The Hospital for Sick Children, TorontoUG1HL135680 · NHLBI · HOSPITAL FOR SICK CHLDRN (TORONTO) · PI MCCRINDLE, BRIAN W, MITAL, SEEMA · 2017 to 2023
$1.7M
NHLBI NIH HHS U24 HL135691NHLBI NIH HHS UG1 HL135646NHLBI NIH HHS UG1 HL135665NHLBI NIH HHS UG1 HL135666NHLBI NIH HHS UG1 HL135678NHLBI NIH HHS UG1 HL135680NHLBI NIH HHS UG1 HL135682NHLBI NIH HHS UG1 HL135683NHLBI NIH HHS UG1 HL135685NHLBI NIH HHS UG1 HL135689
6 · The paper itself

Abstract

backgroundIn the FUEL (Fontan Udenafil Exercise Longitudinal) trial, a positive treatment effect was identified for outcomes at the ventilatory anaerobic threshold but not for the primary outcome, oxygen consumption (Vo

methodsParticipants were divided into subgroups by baseline predicted peak Vo

resultsOf the 379 participants with paired exercise data, 302 (80%) had a baseline peak Vo

conclusionsIn this post hoc subgroup analysis, after exclusion of patients with Fontan circulation with near-normal baseline peak Vo REGISTRATION: URL: https://clinicaltrials.gov; Unique identifier: NCT0274115.

Indexed as

Exercise ToleranceFontan ProcedureHeart Defects, CongenitalPhosphodiesterase 5 InhibitorsPyrimidinesSulfonamidesAdolescentAnaerobic ThresholdBenzenesulfonamidesChildDouble-Blind MethodExercise TestFemaleHumansMaleOxygen ConsumptionBenzenesulfonamidesPhosphodiesterase 5 InhibitorsPyrimidinesSulfonamidesudenafilexerciseFontanudenafil

Identifiers

PMID40792599
PMCPMC12533643

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.