Observational study in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
11 authors.
Chunxiao ZhangDivision of Epidemiology and Community Health, School of Public Health University of Minnesota Minneapolis MN USA.ORCID 0000-0002-5166-2560
Wendy WangDepartment of Epidemiology, Peter O'Donnell Jr. School of Public Health UT Southwestern Medical Center Dallas TX USA.ORCID 0000-0001-6025-0173
Riccardo M InciardiDivision of Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University of Brescia Brescia Italy.ORCID 0000-0003-4846-8529
Yuekai JiDepartment of Epidemiology, Bloomberg School of Public Health Johns Hopkins University Baltimore MD USA.
Khaled ShelbayaDepartment of Internal Medicine UT Southwestern Medical Center Dallas TX USA.ORCID 0000-0001-6233-8013
Anne EatonDivision of Biostatistics & Health Data Science, School of Public Health University of Minnesota Minneapolis MN USA.ORCID 0000-0001-5900-9745
Alvaro AlonsoDepartment of Epidemiology, Rollins School of Public Health Emory University Atlanta GA USA.ORCID 0000-0002-2225-8323
Elsayed Z SolimanSchool of Medicine Wake Forest University Winston-Salem NC USA.ORCID 0000-0001-5632-8150
Scott D SolomonDivision of Cardiovascular Medicine Brigham and Women's Hospital, Harvard Medical School Boston MA USA.ORCID 0000-0003-3698-9597
Amil M ShahDepartment of Internal Medicine UT Southwestern Medical Center Dallas TX USA.ORCID 0000-0003-1056-4451
Lin Yee ChenLillehei Heart Institute and Cardiovascular Division University of Minnesota Medical School Minneapolis MN USA.ORCID 0000-0002-0700-814X
Funding
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - COORDINATING CENTER - TASK AREA B.2 AND B.375N92022D00001 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID · 2022 to 2025
$13.7M
Mapping the Progression to HFpEF in the Elderly through Longitudinal Changes in Cardiac FunctionR01HL135008 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Amil M Shah · 2017 to 2026
$11.5M
Cardiovascular Disease Epidemiology &Prevention TrngT32HL007779 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI PAMELA L. Lutsey, JAMES S PANKOW · 1994 to 2026
$9.3M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00003 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2022 to 2025
$5.1M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00005 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WAGENKNECHT, LYNNE E · 2022 to 2025
$5.0M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00004 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI WINDHAM, BEVERLY GWEN · 2022 to 2025
$4.8M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00002 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CORESH, JOSEF · 2022 to 2025
$4.7M
Early Detection of Transthyretin Cardiac Amyloidosis: Defining a Novel Target for HFpEF Treatment and Prevention in Late LifeR01HL150342 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DORBALA, SHARMILA, SHAH, AMIL M · 2020 to 2023
$4.1M
Quantifying cardiac structure and function to define the progression to hear failure in African AmericansR01HL143224 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI SHAH, AMIL M · 2018 to 2021
$3.4M
Proteomic signatures to identifypathways underlying the progression toheart failureR01HL148218 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI SHAH, AMIL M, YU, BING · 2020 to 2023
$3.4M
Contributions of pulmonary arterial and venous remodeling to HFpEF in the elderlyR01HL160025 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI SAN JOSE ESTEPAR, RAUL, SHAH, AMIL M · 2022 to 2025
$3.0M
Left Atrial Abnormality and Atrial Fibrillation-Related Cerebral Infarcts and Cognitive DeclineR01HL141288 · NHLBI · UNIVERSITY OF MINNESOTA · PI CHEN, LIN YEE · 2018 to 2021
backgroundLower left atrial (LA) function may precede LA enlargement and contribute to mitral regurgitation (MR). We examined the association of LA reservoir strain (a measure of LA function) with MR in the ARIC (Atherosclerosis Risk in Communities) study.
methodsWe analyzed ARIC participants with echocardiograms at Visits 5 (2011-2013) and 7 (2018-2019). LA reservoir strain was measured at Visit 5. MR was diagnosed by echocardiography. The cross-sectional association was assessed at Visit 5, and the prospective association was examined through Visit 7 using multivariable logistic regression.
resultsIn the cross-sectional analysis (n=4689, mean age 75.2±5.0 years, 60.2% female, 19.9% Black), 1927 participants (41.1%) had prevalent MR. Each 1-SD (7.53%) lower LA reservoir strain was associated with higher odds of prevalent MR (odds ratio [OR], 1.12 [95% CI, 1.04-1.20]). In the prospective analysis (n=1480, mean age 73.5±4.2 years, 54.9% female, 22.6% Black), 409 participants developed MR. A 1-SD (6.71%) lower LA reservoir strain was associated with higher odds of incident MR (OR, 1.18 [95% CI, 1.04-1.34]); the association was partially attenuated after adjusting for post-Visit 5 heart failure and atrial fibrillation (OR, 1.14 [95% CI, 1.00-1.30]) and further attenuated after adjusting for LA volume index from Visit 5 (OR, 1.11 [95% CI, 0.98-1.27]).
conclusionsLA reservoir strain is associated with prevalent and incident MR in older adults. The association between lower LA reservoir strain and incident MR may be partially explained by LA enlargement, apart from atrial fibrillation and heart failure.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Association of Left Atrial Function With Mitral Regurgitation: The Atherosclerosis Risk in Communities Study. · full record | OpenQuestion