Evidence map›Paper›PMID 40792585›Full record

ArticleJournal of the American Heart Association2025

Atrial Natriuretic Peptide at Discharge as a Predictive Marker for Early Rehospitalization in Patients With Heart Failure With Preserved Ejection Fraction.

Junichi Ohno, Kyung-Duk Min, Isamu Sunayama, Yuki Matsumoto, Aika Daimon, Eri Manabe, Makiko Oboshi, Kohei Azuma, Masataka Sugahara, Akiyo Eguchi and 3 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Junichi OhnoDepartment of Cardiovascular and Renal Medicine Hyogo Medical University Nishinomiya Hyogo Japan.
Kyung-Duk MinDepartment of Cardiovascular and Renal Medicine Hyogo Medical University Nishinomiya Hyogo Japan.
Isamu SunayamaDepartment of Cardiovascular and Renal Medicine Hyogo Medical University Nishinomiya Hyogo Japan.
Yuki MatsumotoDepartment of Cardiovascular and Renal Medicine Hyogo Medical University Nishinomiya Hyogo Japan.
Aika DaimonDepartment of Cardiovascular and Renal Medicine Hyogo Medical University Nishinomiya Hyogo Japan.
Eri ManabeDepartment of Cardiovascular and Renal Medicine Hyogo Medical University Nishinomiya Hyogo Japan.ORCID 0000-0002-4474-4269
Makiko OboshiDepartment of Cardiovascular and Renal Medicine Hyogo Medical University Nishinomiya Hyogo Japan.ORCID 0000-0002-0592-657X
Kohei AzumaDepartment of Cardiovascular and Renal Medicine Hyogo Medical University Nishinomiya Hyogo Japan.
Masataka SugaharaDepartment of Cardiovascular and Renal Medicine Hyogo Medical University Nishinomiya Hyogo Japan.ORCID 0000-0001-7951-4706
Akiyo EguchiDepartment of Cardiovascular and Renal Medicine Hyogo Medical University Nishinomiya Hyogo Japan.
Yoshiro NaitoDepartment of Cardiovascular and Renal Medicine Hyogo Medical University Nishinomiya Hyogo Japan.ORCID 0000-0002-9859-7153
Masanori AsakuraDepartment of Cardiovascular and Renal Medicine Hyogo Medical University Nishinomiya Hyogo Japan.ORCID 0009-0006-5714-3397
Masaharu IshiharaDepartment of Cardiovascular and Renal Medicine Hyogo Medical University Nishinomiya Hyogo Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients admitted for heart failure with preserved ejection fraction (HFpEF) are at risk for rehospitalization, especially within 90 days post discharge. NPs (natriuretic peptides), namely ANP (atrial NP) and BNP (brain NP), are important biomarkers in HF management, but their role in predicting early rehospitalization in patients with HFpEF remains unclear.

methodsA retrospective analysis was conducted on 147 patients with HFpEF hospitalized for HF. ANP and BNP levels were measured at admission and discharge. Rehospitalization events were analyzed to evaluate the prognostic impact of NPs.

resultsAmong 147 patients, 47 (32.0%) were rehospitalized within 1 year, including 22 (15.0%) within the 90 days postdischarge. Elevated discharge ANP (>113 pg/mL) was significantly associated with early rehospitalization (log-rank

conclusionsDischarge ANP was a robust predictor of early rehospitalization in patients with HFpEF. These findings suggest that incorporating ANP measurements into postdischarge management may improve risk stratification to reduce early rehospitalization in patients with HFpEF.

Indexed as

Atrial Natriuretic FactorHeart FailurePatient DischargePatient ReadmissionStroke VolumeVentricular Function, LeftAgedAged, 80 and overBiomarkersFemaleHumansMaleMiddle AgedNatriuretic Peptide, BrainPredictive Value of TestsPrognosisAtrial Natriuretic FactorBiomarkersNatriuretic Peptide, Brainatrial natriuretic peptide (ANP)discharge assessmentearly rehospitalizationheart failure with preserved ejection fraction (HFpEF)risk stratification

Identifiers

PMID40792585
PMCPMC12533653

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.