Evidence map›Paper›PMID 40792514›Full record

ArticleMicrobiology spectrum2025

IITR00803: a benzoxazole-nitrothiophene small molecule with broad-spectrum antibacterial potential.

Rinki Gupta, Amit Gaurav, Ranjana Pathania

Abstract read
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In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Rinki GuptaDepartment of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, India.ORCID 0000-0002-1777-1632
Amit GauravDepartment of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, India.ORCID 0000-0003-4657-394X
Ranjana PathaniaDepartment of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, India.ORCID 0000-0002-7965-8176

Funding

Department of Biotechnology, Ministry of Science and Technology, India DBT/2018/IIT-R/1144Science and Engineering Research Board EMR/2016/007116
6 · The paper itself

Abstract

The drug discovery of novel antibacterials is pivotal to combat the ever-growing challenge of antibiotic resistance. The current antibiotics in clinics target the essential pathways in bacteria. However, drug efflux among other resistance mechanisms remains a persistent problem, leading to reduced efficacy of antibiotics. In the present study, we report the discovery of a novel small molecule, IITR00803, with antibacterial properties. IITR00803 demonstrated broad-spectrum antibacterial activity with potent inhibition of enteric pathogens. The small molecule contains a benzoxazole group and a nitrothiophene moiety in its chemical structure. The nitrothiophene-based compounds are prone to efflux by AcrAB-TolC efflux pumps. Despite containing the nitrothiophene group, IITR00803 did not demonstrate efflux liability, thereby demonstrating a broad antibacterial spectrum. The small molecule depicted bactericidal activity against

Indexed as

Anti-Bacterial AgentsBenzoxazolesThiophenesAnimalsCaenorhabditis elegansDrug DiscoveryEscherichia coliHumansMicrobial Sensitivity TestsSalmonella typhimuriumAnti-Bacterial AgentsBenzoxazolesThiophenesantibacterial small moleculeantibiotic resistanceDNA damagedrug discoverynitrothiophene

Identifiers

PMID40792514
PMCPMC12403614

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.