Evidence map›Paper›PMID 40792512›Full record

ArticleMicrobiology spectrum2025

The role of the S1 gene in glandular stomach pathogenesis and tropism of infectious bronchitis virus H120 strain in poultry.

Zhenkai Dai, Yutao Teng, Jiabei Song, Zhengzhong Xiao, Jing Zhang, Keyu Feng, Guanming Shao, Xinheng Zhang, Qingmei Xie

Abstract read
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In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Zhenkai Dai *State Key Laboratory of Swine and Poultry Breeding Industry & Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, P. R. China.ORCID 0000-0003-3548-8694
Yutao Teng *State Key Laboratory of Swine and Poultry Breeding Industry & Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, P. R. China.
Jiabei SongState Key Laboratory of Swine and Poultry Breeding Industry & Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, P. R. China.
Zhengzhong XiaoSchool of Biology and Agriculture, Shaoguan University, Shaoguan, P. R. China.
Jing ZhangState Key Laboratory of Swine and Poultry Breeding Industry & Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, P. R. China.
Keyu FengState Key Laboratory of Swine and Poultry Breeding Industry & Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, P. R. China.
Guanming ShaoState Key Laboratory of Swine and Poultry Breeding Industry & Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, P. R. China.
Xinheng ZhangState Key Laboratory of Swine and Poultry Breeding Industry & Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, P. R. China.
Qingmei XieState Key Laboratory of Swine and Poultry Breeding Industry & Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, P. R. China.ORCID 0000-0001-6537-7798

Funding

construction project of modern agricultural science and technology innovation alliance in Guangdong province 2024CXTD20Provincial Science and Technology Special Fund Project for Zhongshan City 2021sdr003the China Agriculture Research System of MOF and MARA CARS-42-13the China Laboratory of Lingnan Modern Agriculture Project NT2025005the Science and Technology Program of Guangdong province 2023B0202010029
6 · The paper itself

Abstract

Infectious bronchitis virus (IBV) H120 strain, a widely used vaccine in poultry production, has been associated with an increased incidence of avian glandular and muscular stomach inflammation. This study aimed to investigate the pathogenic factors of stomach inflammation induced by the IBV H120 vaccine and identify genetic regions affecting glandular and muscular stomach lesions through the construction of recombinant strains. Our findings revealed that the H120 strain exhibits a more pronounced tropism for the glandular and muscular stomach compared to the 4/91 strain. Notably, the replacement of the S1 gene in the H120 strain resulted in reduced pathogenicity in the chicken's glandular stomach. These results suggest that the S1 gene of the H120 strain plays a critical role in viral replication within the chicken stomach, contributing to the development of muscular and glandular stomach lesions. This research provides valuable insights into the pathogenesis of IBV and offers potential strategies for optimizing vaccine strains by targeting the S1 gene to minimize viral load in the glandular and muscular stomachs, ultimately improving poultry health and productivity. IMPORTANCE: Infectious bronchitis virus (IBV) causes high morbidity and mortality worldwide, leading to significant economic losses. While the widespread vaccination with the H120 strain has effectively curbed the spread of IBV, we have discovered that the H120 strain can cause glandular stomach inflammation in chickens. Further research indicates that the S1 gene of the H120 strain determines its tropism for the glandular stomach. Studying the glandular tropism of the H120 strain is crucial for developing effective and safe IBV vaccines.

Indexed as

Coronavirus InfectionsInfectious bronchitis virusPoultry DiseasesSpike Glycoprotein, CoronavirusStomachViral TropismAnimalsChickensViral VaccinesVirus ReplicationSpike Glycoprotein, Coronavirusspike protein, avian infectious bronchitis virusViral Vaccinesglandular and muscular stomachH120 strainInfectious bronchitis virusS1 gene

Identifiers

PMID40792512
PMCPMC12403985

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.