Evidence map›Paper›PMID 40792507›Full record

ArticleMicrobiology spectrum2025

Investigating the mechanism of heat-shock protection in ISKNV-infected tilapia brain cell line.

Angela Naa Amerley Ayiku, Irene Amoakoh Owusu, David Verner-Jeffreys, Richard Paley, Peter Kojo Quashie, Samuel Duodu

Abstract read
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In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Angela Naa Amerley AyikuDepartment of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana.
Irene Amoakoh OwusuWest African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Accra, Ghana.
David Verner-JeffreysWorldFish, Bayan Lepas, Penang, Malaysia.
Richard PaleyCefas Weymouth Laboratory, Centre for Environment, Fisheries and Aquaculture Science, Weymouth, England, United Kingdom.
Peter Kojo QuashieWest African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Accra, Ghana.
Samuel DuoduDepartment of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana.ORCID 0000-0003-2791-8949

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infectious spleen and kidney necrosis virus (ISKNV) is the causative agent of a fatal disease in many fish species, resulting in mass mortalities and significant economic losses. Since its introduction to Ghana in late 2018 and in the absence of effective vaccines, the crude practice of heat-shock treatment (HST) on deliberately exposed cultured tilapia fingerlings was widely adopted by farmers to control the disease in Ghana with some apparent success. This study investigated the interplay between the expression of heat-shock proteins (HSPs) and viral replication during ISKNV infection. An

Indexed as

Fish DiseasesHeat-Shock ResponseIridoviridaeTilapiaAnimalsBrainCell LineHeat-Shock ProteinsVirus ReplicationHeat-Shock Proteinsapoptosisautophagyheat-shockISKNV

Identifiers

PMID40792507
PMCPMC12403615

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.