Evidence map›Paper›PMID 40792484›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Three Is Better than One: A Multimetal Complex that Triggers Immunogenic Cell Death.

Tomer Babu, Matthew S Levine, Sourav Acharya, Esther Y Maier, Jonathan L Sessler

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Three Is Better than One: A Multimetal Complex that Triggers Immunogenic Cell Death.Angewandte Chemie (International ed. in English) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tomer BabuDepartment of Chemistry, The University of Texas at Austin, 105 East 24th Street, Austin, Texas, 78712-1224, USA.ORCID 0000-0002-7106-3629
Matthew S LevineDepartment of Chemistry, The University of Texas at Austin, 105 East 24th Street, Austin, Texas, 78712-1224, USA.ORCID 0000-0002-2622-2678
Sourav AcharyaInstitute for Drug Research, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, 9112102, Israel.ORCID 0000-0001-5511-1312
Esther Y MaierInnovation for Health Institute, College of Pharmacy, The University of Texas at Austin, 1400 Barbara Jordan Blvd, Austin, Texas, 78723, USA.
Jonathan L SesslerDepartment of Chemistry, The University of Texas at Austin, 105 East 24th Street, Austin, Texas, 78712-1224, USA.ORCID 0000-0002-9576-1325

Funding

Biomedical Applications of Expanded Porphyrins: Development of Gold-Texaphyrin ConjugatesR01CA068682 · NCI · UNIVERSITY OF TEXAS AUSTIN · PI Esther Y. Maier, Emily L Que · 1995 to 2026
$7.4M
Fulbright AssociationNCI NIH HHS CA 068682NCI NIH HHS R01 CA068682Welch Foundation F-0018
6 · The paper itself

Abstract

Immunogenic cell death (ICD) is a form of regulated cell death capable of stimulating an adaptive immune response through release of damage-associated molecular patterns (DAMPs). While several metal complexes have shown promise as ICD inducers, conjugates containing more than one metal center remain to be explored for ICD. Here, we report the design, synthesis, and evaluation of a tri-metallic Au

Indexed as

Antineoplastic AgentsCoordination ComplexesImmunogenic Cell DeathProdrugsAnimalsCell Line, TumorGoldHumansMiceOxaliplatinReactive Oxygen SpeciesRutheniumAntineoplastic AgentsCoordination ComplexesGoldOxaliplatinProdrugsReactive Oxygen SpeciesRutheniumGold(I) N‐heterocyclic carbenesImmunogenic cell deathMetals in medicinePlatinum(IV) prodrugsRuthenium(II) 2‐pyridinecarbothioamides

Identifiers

PMID40792484
PMCPMC12455390

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.