ArticleCancer medicine2025
Super-Resolution Ultrasound Radiomics Can Predict the Upstaging of Ductal Carcinoma In Situ.
Article in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Application of Artificial Intelligence in Breast Ultrasound Diagnosis.Diagnostics (Basel, Switzerland) · 2026Review
- Super-Resolution Ultrasound Radiomics Can Predict the Upstaging of Ductal Carcinoma In Situ.Cancer medicine · 2025Article
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Authors and funding
13 authors.
Funding
Abstract
introductionPreoperatively distinguishing pure ductal carcinoma in situ (DCIS) from upstaged DCIS is important for deciding optimal surgical strategies. However, it is hard to preoperatively predict the upstaging of biopsy-proven DCIS. This study aims to develop an effective radiomics model for predicting the upstaging of DCIS based on super-resolution (SR) ultrasound images.
methodsIn this multicentre retrospective study, patients with biopsy-proven DCIS who underwent ultrasound examination were included. A super-resolution reconstruction algorithm was used to enhance the resolution of original high resolution (HR) ultrasound images and obtain SR images. Pyradiomics was used for feature extraction. The selected HR radiomics features and SR radiomics features were combined with clinical features to construct the HR fusion model and SR fusion model, respectively. The area under the receiver operating characteristic curve (AUC) of the models and radiologists was analyzed and compared by the Delong test.
resultsA total of 681 women (median age, 47 years; interquartile range, 42-54) with 681 biopsy-proven DCIS lesions were included, with 422 lesions in the training set, 106 lesions in the validation set, and 153 lesions in the external test set. The SR Fusion model achieved an AUC of 0.819 (0.732-0.887) in the validation set and 0.800 (95% CI 0.728-0.860) in the external test set. It outperformed the radiologists (AUC = 0.603-0.627; p < 0.001) in the validation set. Additionally, it surpassed the clinical model (AUC = 0.682, 95% CI 0.602-0.755; p = 0.02) and the HR Fusion model (AUC = 0.724, 95% CI 0.646-0.793; p = 0.03) in the external test set.
conclusionThe SR Fusion model integrating SR features and clinical features can effectively predict the upstaging of DCIS.
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