ArticleCureus2025
Systemic Immune-Inflammation Index (SII) of Patients With and Without Diabetic Neuropathy: A Cross-Sectional Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Article
- Cervical spinal cord enlargement and systemic inflammation in diabetic peripheral neuropathy: a cross-sectional MRI study.Irish journal of medical science · 2026Article
- Article
- C-reactive Protein-Albumin-Lymphocyte (CALLY) Index in Patients With Sepsis: An Observational Study.Cureus · 2026Article
- Prognostic Nutritional Index (PNI) in Patients With Diabetes and Sepsis: A Cross-Sectional Study.Cureus · 2026Article
- Systemic Inflammatory Response Index (SIRI) Among Patients With Sepsis: A Retrospective Observational Study.Cureus · 2026Article
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Authors and funding
7 authors.
Funding
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Abstract
BACKGROUND AND
objectivesDiabetic neuropathy is a common microvascular complication of type 2 diabetes mellitus (T2DM), like diabetic retinopathy and nephropathy. The neutrophil count is raised during infection and inflammation, and the lymphocyte count is decreased in immunocompromised patients. The platelet count suggests the thrombotic and inflammatory conditions. Hence, the neutrophil-lymphocyte ratio (NLR) is the ratio of absolute counts of neutrophils to lymphocytes. The systemic immune-inflammation index (SII) is the product of NLR and platelet count. These indicate the immuno-inflammatory status of the patient. There is a dearth of literature assessing the SII of individuals with diabetic neuropathy. Hence, we mapped this study to evaluate and compare complete blood count (CBC), NLR, and SII of diabetic patients with and without neuropathy. We also correlated NLR and SII values of the study population.
methodsThis cross-sectional study was conducted from April 2024 to March 2025 at Kalinga Institute of Medical Sciences (KIMS), Bhubaneswar, India. We included adult diabetic patients admitted to the KIMS medicine ward. Hemoglobin, total leucocyte count (TLC), neutrophil count, lymphocyte count, platelet count, length of T2DM, and glycated hemoglobin (HbA
resultsOne hundred ninety-three diabetic patients were found eligible for this study. Their median age was 66 (55-73) years. Of them, 92 (47.7%) were women. The study population's median white blood cell (WBC) was 9.88 (8.72-11.24) × 10
conclusionDiabetes patients without neuropathy and those with neuropathy had comparable CBC, NLR, and SII values. The results of our study cannot be extrapolated due to the limited sample size and failure to account for several variables, including concurrent medications, comorbidities, and length of hospital stay.
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