ArticleCureus2025
Knee Pain: The Fine Line Between Malignant and Benign.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Focal periphyseal edema with atypical MRI features: Biopsy findings and imaging follow-up.Radiology case reports · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Focal periphyseal edema (FOPE) is a normal physiological finding that is often incidentally discovered on MRI of the knee. FOPE zones are areas of periphyseal edema typically observed near the time of physeal closure. This common physiologic phenomenon is related to changes in the distribution of forces around the physis as it closes during adolescence, occurring more frequently in females between 11 and 14 years of age. The condition may be associated with pain or may be asymptomatic. It is often mistaken for pathological bone marrow edema or a Salter-Harris fracture. We present the case of a 14-year-old female patient with chronic knee pain and no history of trauma. MRI revealed two FOPE zones in the distal femur, with no other abnormalities. The patient was managed conservatively with observation and physical therapy, resulting in gradual symptom resolution. This case reinforces that FOPE should be recognized as a normal variant in adolescent knees to avoid misdiagnosis and unnecessary treatment.
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