ArticleFrontiers in human neuroscience2025
Dual 500-μs wide pulse neuromuscular electrical stimulation enhancing sensorimotor cortical excitability.
Article in Frontiers in human neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Neuromuscular electrical stimulation (NMES) is an effective tool to improve motor activation of patients with motor dysfunction. However, to enhance the cortical activities induced by NMES, the corresponding strategies should be carefully designed with optimal stimulation parameters. The aim of the present study is to investigate whether the pulse assignment with wide-pulse-based Variable Frequency Trains improves sensorimotor cortical excitability. Methods: A block-designed experiment was conducted with NMES delivering current to right biceps brachii muscle in nine healthy right-handed adults to evoke repetitive elbow flexion under similar kinetic parameters ( Results: Although evoking similar elbow flexion movements, variable-frequency trains (VFT) could induce stronger cortical activities than constant-frequency trains (CFT). Moreover, the sensorimotor cortex responded significantly more preferably to the dual 500 μs wide pulse VFT (wDFT) stimulation pattern ( Conclusion: The VFT pattern, especially dual 500 μs wide pulse VFT, could enhance sensorimotor cortical excitability, and the central neural activities improvements may attribute to the fact that more afferent fibers are effectively activated. Therefore, our findings indicated the high potential of utilizing DFT with wide pulses to optimize NMES applications in motor rehabilitation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.