Evidence map›Paper›PMID 40792169›Full record

ArticleTranslational cancer research2025

Nicotine-induced PD-L1 expression in lung squamous cell carcinoma is mediated by the α7-nAChR/STAT3 signaling pathway.

Yinan Li, Wenting Wang, Yaoyao Wang, Ce Zhou, Xin Zou, Yixuan Wang, Ning Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Smoking-Induced STC2Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yinan LiDepartment of Respiratory and Critical Medicine, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
Wenting WangDepartment of Oncology, Qingdao Municipal Hospital, University of Health and Rehabilitation Sciences, Qingdao, China.
Yaoyao WangDepartment of Respiratory and Critical Medicine, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
Ce ZhouDepartment of Rehabilitation, Qingdao Municipal Hospital, University of Health and Rehabilitation Sciences, Qingdao, China.
Xin ZouDepartment of Respiratory and Critical Medicine, Qingdao Municipal Hospital, University of Health and Rehabilitation Sciences, Qingdao, China.
Yixuan WangDepartment of Respiratory and Critical Medicine, Qingdao Municipal Hospital, University of Health and Rehabilitation Sciences, Qingdao, China.
Ning WangDepartment of Respiratory and Critical Medicine, Qingdao Municipal Hospital, University of Health and Rehabilitation Sciences, Qingdao, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Nicotine, the principal addictive component of tobacco smoke, promotes lung cancer cell proliferation via α7 nicotinic acetylcholine receptors (α7-nAChRs). Programmed death-ligand 1 (PD-L1) serves as a crucial predictive biomarker for immune checkpoint inhibitor (ICI) therapy in lung squamous cell carcinoma (LUSC). This study aimed to investigate the expression patterns of α7-nAChR and its encoding gene Methods: Results: Conclusions: α7-nAChR and its encoding gene

Indexed as

nicotineprogrammed death-ligand 1 (PD-L1)signal transducer and activator of transcription 3 (STAT3)squamous cell carcinomaα7 nicotinic acetylcholine receptor (α7-nAChR)

Identifiers

PMID40792169
PMCPMC12335717

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.