ArticleTranslational cancer research2025
Identification and validation of anoikis-related differentially expressed genes in nasopharyngeal carcinoma.
Article in Translational cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Integrated Analysis of the LncRNA-Mediated ceRNA Network Associated With Prognosis in Posttreatment Recurrent Nasopharyngeal Carcinoma.Journal of cellular and molecular medicine · 2025Article
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9 authors.
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Abstract
Background: Anoikis resistance is a critical feature enabling cancer cells to survive during detachment from the extracellular matrix. This study aimed to identify and validate anoikis-related differentially expressed genes (ARDEGs) in nasopharyngeal carcinoma (NPC), providing new insights into the molecular mechanisms underlying NPC progression and potential therapeutic targets. Methods: Four gene expression datasets from the Gene Expression Omnibus (GEO) database were integrated to form the GEO-Combined dataset. NPC and adjacent normal nasopharyngeal tissues comprising the Test_Data were subjected to RNA sequencing. The differentially expressed genes (DEGs) from the GEO-Combined and Test_Data datasets were screened. DEGs associated with anoikis were identified and termed as ARDEGs. The key genes were validated by quantitative real-time polymerase chain reaction (qRT-PCR). Results: A total of 104 ARDEGs were identified in our study. Five key genes (i.e., Conclusions: The identification and validation of ARDEGs in NPC highlighted critical molecular players in anoikis resistance, offering potential targets for therapeutic interventions. Our study provides a comprehensive understanding of the role of ARDEGs in NPC, paving the way for further research into targeted therapies for NPC.
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