Evidence map›Paper›PMID 40792100›Full record

ArticleFrontiers in cellular and infection microbiology2025

Respiratory microbiome and metabolome features associate disease severity and the need for doxycycline treatment in children with macrolide-resistant

Wei-Chao Liao, Shiao-Wen Li, En-Wei Hsing, Sung-Han Hsiao, Ian Yi-Feng Chang, Yin-Cheng Chen, Yi-Yin Chen, Yi-Jiun Pan, Yu-Chia Hsieh

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Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wei-Chao LiaoMolecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan.
Shiao-Wen LiDepartment of Life Sciences, National University of Kaohsiung, Kaohsiung, Taiwan.
En-Wei HsingDepartment of Pediatrics, Chang Gung Children's Hospital, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan.
Sung-Han HsiaoDivision of Infectious Diseases, Department of Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Ian Yi-Feng ChangMolecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan.
Yin-Cheng ChenInstitute of BioMedical Informatics, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Yi-Yin ChenGraduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Yi-Jiun PanDepartment of Microbiology and Immunology, School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Yu-Chia HsiehDepartment of Pediatrics, Chang Gung Children's Hospital, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Commensal bacterial community along the upper respiratory tract functions against pathogens. The host determinants of Methods: From 2017 to 2020, 92 children with MRMP-mediated pneumonia were enrolled among 845 children with community-associated pneumonia. Oropharyngeal samplings were collected within 48 h after admission. We compared respiratory microbiome and metabolites based on patients' later development of prolonged fever and the need for doxycycline treatment (DT, Results: Significantly higher diversity and different respiratory microbiomes were evaluated in WDT patients in contrast to DT patients. Conclusions: Microbiota dysbiosis with dysregulated inflammatory glycerolphospholipid-related metabolites was related to disease severity and the need for doxycycline treatment in children with MRMP-mediated pneumonia. Anaerobic bacteria metabolites and metabolic pathway could be beneficial therapeutic targets against

Indexed as

Anti-Bacterial AgentsDoxycyclineDrug Resistance, BacterialMacrolidesMetabolomeMicrobiotaMycoplasma pneumoniaePneumonia, MycoplasmaBacteriaChildChild, PreschoolCommunity-Acquired InfectionsFemaleHumansInfantMaleAnti-Bacterial AgentsDoxycyclineMacrolidesRNA, Ribosomal, 16Sdisease severitymacrolide-resistant Mycoplasma pneumoniaemetabolomemicrobiomeMycoplasma pneumoniaepneumoniarespiratory

Identifiers

PMID40792100
PMCPMC12336209

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.