ArticleLaryngoscope investigative otolaryngology2025
Saddle Nose in Granulomatosis With Polyangiitis (GPA) vs. Non-GPA Patients With Septal Perforations.
Article in Laryngoscope investigative otolaryngology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Saddle Nose in Granulomatosis With Polyangiitis (GPA) vs. Non-GPA Patients With Septal Perforations.Laryngoscope investigative otolaryngology · 2025Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Saddle nose deformity (SND) can be associated with nasal septal perforation (NSP). Both SND and NSP are observed in granulomatosis with polyangiitis (GPA) patients. This study aimed to compare the prevalence and severity of SND in GPA vs. non-GPA patients with NSP. Methodology: NSP patients who visited tertiary rhinology or facial plastic surgery clinics from January 2010 through December 2023 were grouped into GPA and non-GPA cohorts. The area of NSP, SND incidence, and SND severity (Daniel and Brenner's classification) were compared between the cohorts. Results: Of 168 patients identified with NSP, 18 had GPA and 150 had non-GPA diagnoses. Twelve GPA patients and 10 non-GPA patients had SND. The odds ratio for SND association in GPA patients with NSP vs. non-GPA patients was 31.3 (95% CI: 9.5-102.9), and 19.4 (95% CI: 4.3-87.7) after controlling for the NSP area. GPA patients with SND had a larger NSP area (median 670 mm Conclusion: GPA diagnosis was associated with larger NSPs and a higher risk of SND compared to non-GPA etiologies; however, the severity of saddling did not differ between GPA and non-GPA etiologies. GPA is an independent risk factor associated with SND irrespective of the size of septal perforation. The NSP area did not predict the severity of SND.
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