ArticleCurrent therapeutic research, clinical and experimental2025
Randomized, Double-Blind, Crossover Study Comparing the Bioavailability of 4 Ashwagandha (
Article in Current therapeutic research, clinical and experimental, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The trial behind it
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Who cites it
2 citing papers in PubMed.
- Withanolides Are Detected in Human Urine Following Oral Administration of aInternational journal of molecular sciences · 2026Article
- A review of protective effects ofFrontiers in pharmacology · 2026Review
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Authors and funding
2 authors.
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Abstract
Background: Objective: This study aimed to evaluate and compare the oral bioavailability of 4 commercially standardized ashwagandha extracts under fasting conditions in healthy adults. Methods: This randomized, double-blind, 4-treatment, 4-period, 4-sequence, single dose, 4-way crossover study was conducted in 16 healthy human volunteers. Participants received a single oral dose of 1 of 4 ashwagandha extracts, with varying compositions of 35% ( Results: Conclusions: These findings emphasize the critical role of withanolide glycosides in determining the PK performance of ashwagandha supplements. The enhanced bioavailability of WS-35 supports its preferential use in therapeutic applications and provides a strong rationale for further investigation into dose-response relationships and the long-term efficacy of standardized, high-bioavailability formulations. Clinical Trial Registry of India identifier: CTRI/2020/10/028397.
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