Evidence map›Paper›PMID 40792032›Full record

ArticleiScience2025

Multi-omics whole-genome characterization of the copy number landscape of metastatic pancreatic ductal adenocarcinoma.

James T Topham, Joanna M Karasinska, Andrew Metcalfe, Hassan A Ali, Steve E Kalloger, Maya Kevorkova, Emma Titmuss, Gian Luca Negri, Sandra E Spencer, Gun Ho Jang and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

James T TophamPancreas Centre BC, Vancouver, BC, Canada.
Joanna M KarasinskaPancreas Centre BC, Vancouver, BC, Canada.
Andrew MetcalfePancreas Centre BC, Vancouver, BC, Canada.
Hassan A AliPancreas Centre BC, Vancouver, BC, Canada.
Steve E KallogerPancreas Centre BC, Vancouver, BC, Canada.
Maya KevorkovaPancreas Centre BC, Vancouver, BC, Canada.
Emma TitmussDivision of Medical Oncology, BC Cancer, Vancouver, BC, Canada.
Gian Luca NegriCanada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC, Canada.
Sandra E SpencerCanada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC, Canada.
Gun Ho JangOntario Institute for Cancer Research, Toronto, ON, Canada.
Grainne M O'KaneOntario Institute for Cancer Research, Toronto, ON, Canada.
Richard A MooreCanada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC, Canada.
Andrew J MungallCanada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC, Canada.
Jonathan M LoreeDivision of Medical Oncology, BC Cancer, Vancouver, BC, Canada.
Faiyaz NottaOntario Institute for Cancer Research, Toronto, ON, Canada.
Julie M WilsonOntario Institute for Cancer Research, Toronto, ON, Canada.
Oliver F BatheDepartments of Surgery and Oncology, Cummings School of Medicine, University of Calgary, Calgary, AB, Canada.
Patricia A TangDepartments of Surgery and Oncology, Cummings School of Medicine, University of Calgary, Calgary, AB, Canada.
Rachel GoodwinThe Ottawa Hospital Cancer Centre, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Gregg B MorinCanada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC, Canada.
Jennifer J KnoxUniversity Health Network, University of Toronto, Toronto, ON, Canada.
Steven GallingerOntario Institute for Cancer Research, Toronto, ON, Canada.
Janessa LaskinDivision of Medical Oncology, BC Cancer, Vancouver, BC, Canada.
Marco A MarraCanada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC, Canada.
Steven J M JonesCanada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC, Canada.
Daniel J RenoufPancreas Centre BC, Vancouver, BC, Canada.
David F SchaefferPancreas Centre BC, Vancouver, BC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with limited therapeutic options. While genome profiling has benefitted clinical decision-making in many cancer types, PDAC remains among the most lethal solid cancers and has relatively few clinically actionable molecular targets. Using a multi-omics approach, we integrate whole-genome and transcriptome datasets along with proteomics and clinical metadata to identify copy-altered regions with significant impact on expression at the whole-genome scale. This approach identified

Indexed as

CancerGenomicsProteomicsTranscriptomics

Identifiers

PMID40792032
PMCPMC12337651

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.