Evidence map›Paper›PMID 40792030›Full record

ArticleiScience2025

PIEZO1 mechanical insensitivity in generalized lymphatic dysplasia with the potential for pharmacological rescue.

Melanie J Ludlow, Oleksandr V Povstyan, Deborah M Linley, Silvia Martin-Almedina, Charlotte Revill, Kevin Cuthbertson, Katie A Smith, Emily Fay, Elisavet Fotiou, Andrew Bush and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Piezo channels in tumors.Journal of cancer research and clinical oncology · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Melanie J LudlowLeeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds LS2 9JT, UK.
Oleksandr V PovstyanLeeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds LS2 9JT, UK.
Deborah M LinleyLeeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds LS2 9JT, UK.
Silvia Martin-AlmedinaSchool of Health & Medical Sciences, City St George's, University of London, London SW17 0RE, UK.
Charlotte RevillSchool of Chemistry, University of Leeds, Leeds LS2 9JT, UK.
Kevin CuthbertsonSchool of Chemistry, University of Leeds, Leeds LS2 9JT, UK.
Katie A SmithLeeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds LS2 9JT, UK.
Emily FaySchool of Health & Medical Sciences, City St George's, University of London, London SW17 0RE, UK.
Elisavet FotiouSchool of Health & Medical Sciences, City St George's, University of London, London SW17 0RE, UK.
Andrew BushPaediatric Respiratory Medicine, NHLI, Imperial College London, London, UK.
Claire HoggPaediatric Respiratory Medicine, NHLI, Imperial College London, London, UK.
Tobias LindenDepartment of Neuropediatrics, University Children's Hospital, Klinikum Oldenburg, Oldenburg, Germany.
Natalie B TanVictorian Clinical Genetics Services, Murdoch Children's Research Institute, Parkville, VIC, Australia.
Susan M WhiteVictorian Clinical Genetics Services, Murdoch Children's Research Institute, Parkville, VIC, Australia.
Juan C Del Rey JimenezSouth West Thames Regional Centre for Genomics, St George's University Hospitals NHS Foundation Trust, London SW17 0QT, UK.
Ege SackeySouth West Thames Regional Centre for Genomics, St George's University Hospitals NHS Foundation Trust, London SW17 0QT, UK.
Esther DempseySchool of Health & Medical Sciences, City St George's, University of London, London SW17 0RE, UK.
Sahar MansourSchool of Health & Medical Sciences, City St George's, University of London, London SW17 0RE, UK.
Gregory ParsonageLeeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds LS2 9JT, UK.
Antreas C KalliLeeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds LS2 9JT, UK.
Richard FosterSchool of Chemistry, University of Leeds, Leeds LS2 9JT, UK.
Pia OstergaardSchool of Health & Medical Sciences, City St George's, University of London, London SW17 0RE, UK.
David J BeechLeeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds LS2 9JT, UK.

Funding

Department of Health NIHR203331Medical Research Council MR/P011543/1Wellcome Trust 110044
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cell biologyPharmacology

Identifiers

PMID40792030
PMCPMC12337661

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.