Evidence map›Paper›PMID 40792013›Full record

ArticleBlood neoplasia2025

NAMPT haploinsufficiency is a collateral lethal therapeutic vulnerability in high-risk myeloid malignancies with

Madhavi D Senagolage, Hunter Z Blaylock, Saira Khan, Sarah J Skuli, Martin P Carroll, Megan E McNerney

Abstract read
In one paragraph

Article in Blood neoplasia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Madhavi D SenagolageDepartment of Pathology, The University of Chicago, Chicago, IL.
Hunter Z BlaylockDepartment of Pathology, The University of Chicago, Chicago, IL.
Saira KhanDepartment of Pathology, The University of Chicago, Chicago, IL.
Sarah J SkuliDivision of Hematology and Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Martin P CarrollDivision of Hematology and Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Megan E McNerneyDepartment of Pathology, The University of Chicago, Chicago, IL.

Funding

HEMATOLOGY CLINICAL RESEARCH TRAINING PROGRAMT32HL007439 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI LAWRENCE F BRASS, PETER S KLEIN · 1985 to 2026
$17.1M
Multi-Disciplinary Training Grant in Cancer ResearchT32CA009594 · NCI · UNIVERSITY OF CHICAGO · PI KAY F MACLEOD, Scott A. Oakes · 1989 to 2026
$11.5M
Regulation of hematopoiesis by CUX1R01HL142782 · NHLBI · UNIVERSITY OF CHICAGO · PI MCNERNEY, MEGAN · 2018 to 2022
$2.0M
Establishing CUX1 as a determinant of hematopoietic stem cell fateR01HL166184 · NHLBI · UNIVERSITY OF CHICAGO · PI Megan McNerney · 2023 to 2026
$1.9M
The pathogenesis of chromosome 7q deletions in juvenile myelomonocytic leukemiaR01CA231880 · NCI · UNIVERSITY OF CHICAGO · PI MCNERNEY, MEGAN · 2018 to 2022
$1.8M
Functional characterization of CUX1 regulators for the treatment of myelodysplastic syndromesF32HL156600 · NHLBI · UNIVERSITY OF CHICAGO · PI SENAGOLAGE, MADHAVI DUSHYANTHI · 2021 to 2024
$225k
NCI NIH HHS R01 CA231880NCI NIH HHS T32 CA009594NHLBI NIH HHS F32 HL156600NHLBI NIH HHS R01 HL142782NHLBI NIH HHS R01 HL166184NHLBI NIH HHS T32 HL007439
6 · The paper itself

Abstract

Monosomy 7 (-7) and deletions of chromosome arm 7q (del(7q)) are prevalent high-risk cytogenetic abnormalities that often co-occur with del(17p) (harboring

Identifiers

PMID40792013
PMCPMC12335956

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.