ReviewFrontiers in cell and developmental biology2025
Hydrogel-driven innovations for targeted delivery, immune modulation, and tissue repair in thyroid cancer therapy.
Review in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Research advances in hydrogel-based strategies for thyroid disease management: from diagnosis to therapeutic applications.Frontiers in bioengineering and biotechnology · 2026Review
- Review
- Multimodal spectrum of approach in poorly differentiated thyroid carcinoma (an updated analysis).Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieReview
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Thyroid cancer is the fastest-growing endocrine malignancy globally, with an increasing incidence in younger patients. Conventional therapies, including surgery, radioactive-iodine (RAI) ablation, endocrine suppression, and multi-kinase inhibition, have improved outcomes but are limited by peri-operative morbidity, systemic toxicity, long treatment durations, and the development of drug resistance. Objective: This review synthesizes current advancements in hydrogel-based therapy, focusing on its potential as a multifunctional platform to overcome the challenges in thyroid cancer management. The review highlights the role of hydrogels not only as carriers for various drugs but also as specific agents for thyroid cancer treatment, offering targeted delivery, immune modulation, and tissue repair. Content: Modern hydrogels, with their high biocompatibility, tunable mechanical properties, and responsiveness to external stimuli (pH, temperature, light, enzymes), provide site-specific, sustained release of chemotherapeutics, tyrosine kinase inhibitors (TKIs), and Challenges and Outlook: Several challenges remain, including optimising the degradation kinetics of hydrogels without compromising their mechanical integrity, improving the loading of hydrophobic TKIs, and better understanding the interactions between hydrogels, the immune system, and tumour tissues Conclusion: By integrating precision drug delivery, immune modulation, and tissue engineering into a single platform, hydrogels are positioned to revolutionize the treatment of thyroid cancer. They offer a promising solution for improving locoregional control, minimizing systemic toxicity, and enhancing the survival and quality of life of patients with both differentiated and undifferentiated thyroid cancers. The versatility of hydrogels as carriers for a broad range of therapeutic agents, as well as their specificity for thyroid cancer treatment, highlights their potential to redefine the future of targeted cancer therapies.
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Registered trials
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