ArticleFrontiers in cardiovascular medicine2025
Fetal exposure to famine increases the risk of cardiovascular disease in adulthood: findings from a population-based screening study.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Undernutrition during early life may increase the risk of chronic diseases in adulthood. The study aimed to investigate whether fetal exposure to famine would increase the risk of cardiovascular disease (CVD) in adulthood. Materials and methods: Data were collected from 16 sites in Henan by the China Patient-centered Evaluative Assessment of Cardiac Events (PEACE) Million Persons Project. The famine-exposed group was defined as participants born between 1 January 1959 and 31 December 1961, and the non-exposed group was defined as participants born between 1 January 1955 and 31 December 1957, and those born between 1 January 1963 and 31 December 1965. Multivariate logistic regression models were used to explore the association between fetal exposure to famine and CVD in adulthood, with adjustments for age, sex, education, family's annual income, currently smoking, drinking alcohol, body mass index, anti-hypertensive drugs, anti-diabetic drugs, and lipid-lowering drugs. Results: Fetal exposure to famine increased the risk of total CVD [odds ratio (OR) = 1.25, 95% confidence interval (CI): 1.14-1.38], coronary heart disease (OR = 11.25, 95% CI: 1.05-1.47), stroke (OR = 11.22, 95% CI: 1.09-1.36), and 10-year CVD risk (OR = 11.22, 95% CI: 1.14-1.31) compared with the non-exposed group. The stratified analysis suggested that after being exposed to famine in the fetal period, men had a higher risk of CVD than women in adulthood (men: OR = 11.26, 95% CI: 110-1.44; women: OR = 11.23, 95% CI: 1.12-1.35) and the population in rural areas had a higher risk of CVD than that in urban areas (rural: OR = 11.30, 95% CI: 1.15-1.48; urban: OR = 11.20, 95% CI: 1.05-1.39). Discussion: Fetal exposure to famine increased the risk of total CVD, coronary heart disease, stroke, and 10-year CVD risk in Henan. The association was more pronounced in men and rural areas.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.