Evidence map›Paper›PMID 40791923›Full record

ArticleERJ open research2025

Secretory IgA modifies the association between early-life gut microbiota trajectories and childhood nonatopic wheeze.

Linn E Moore, Hein M Tun, Catherine J Field, Piushkumar J Mandhane, Elinor Simons, Theo J Moraes, Padmaja Subbarao, Stuart E Turvey, Matthew Hicks, Anne Hicks and 1 more

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Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Linn E MooreDepartment of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Hein M TunThe Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Catherine J FieldDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada.
Piushkumar J MandhaneDepartment of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Elinor SimonsDepartment of Pediatrics and Child Health, Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada.
Theo J MoraesDepartment of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.ORCID https://orcid.org/0000-0001-9968-6601
Padmaja SubbaraoDepartment of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.ORCID https://orcid.org/0000-0003-0394-1933
Stuart E TurveyDepartment of Pediatrics, Child and Family Research Institute, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada.ORCID https://orcid.org/0000-0003-1599-1065
Matthew HicksDepartment of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Anne HicksDepartment of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Anita L KozyrskyjDepartment of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Wheezing in childhood is common and evidence is accumulating for the role of the gut microbiome in the development of atopic wheeze. Changes to the early-life gut microbiota and secretory IgA (SIgA) production have been linked to childhood disease; however, their connection to nonatopic wheeze is unknown. The objectives of the present study were to evaluate the relationships between early-life gut microbiota trajectories, SIgA and childhood nonatopic wheeze. Methods: Early-life gut microbiota, SIgA and child outcome data were collected as part of the Canadian Healthy Infant Longitudinal Development (CHILD) cohort study on 1203 children. Gut microbiota trajectories were categorised as C1-C1, C1-C2, C2-C1 and C2-C2 based on low (cluster 1; C1) or high (cluster 2; C2) Results: The main outcome was nonatopic wheeze before age 5 years (n=105). Logistic regression analysis showed the C1-C2 trajectory, of low Conclusions: Nonatopic wheeze is associated with a depletion of

Identifiers

PMID40791923
PMCPMC12336992

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.