ArticleFrontiers in neurology2025
Association between Advanced Lung Cancer Inflammation Index and 30-day mortality in patients with spontaneous intracerebral hemorrhage: a retrospective cohort study.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The predictive value of serological markers for successful weaning and 30-day mortality in patients with severe intracerebral hemorrhage.BMC neurology · 2026Article
- Gastrointestinal dysfunction after brain injury: Mechanisms and the role of the brain-gut axis.World journal of gastroenterology · 2026Review
- Advanced lung cancer inflammation index as a diagnostic indicator of bone turnover in osteoporotic fracture patients: a non-linear analysis.Frontiers in endocrinology · 2025Article
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Authors and funding
8 authors.
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Abstract
Background and purpose: Spontaneous intracerebral hemorrhage (ICH) is a leading cause of stroke-related mortality, with early outcomes significantly influenced by inflammation and malnutrition. However, the prognostic value of composite biomarkers, which integrate multiple factors such as inflammation and nutritional status, remains insufficiently explored, particularly in the context of early outcomes following ICH. This study explores the association between the Advanced Lung Cancer Inflammation Index (ALI) and 30-day mortality in ICH patients, evaluating its prognostic value as a composite biomarker that integrates body mass index (BMI), serum albumin, and neutrophil-to-lymphocyte ratio (NLR). Methods: A retrospective cohort study was conducted on 2,459 ICH patients from a single institution, West China Hospital, between January 2009 and June 2019. ALI was calculated using the formula ALI = (BMI × Alb)/NLR, and patients were stratified into quartiles based on ALI scores. The primary outcome was 30-day mortality, and logistic regression analysis was employed to evaluate the association between ALI and mortality. Results: The 30-day mortality rate was 23.3% ( Conclusion: ALI is a reliable composite biomarker, with higher ALI scores being significantly associated with reduced 30-day mortality in patients with ICH.
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