ReviewJOR spine2025
Central Pattern Generators in Spinal Cord Injury: Mechanisms, Modulation, and Therapeutic Strategies for Motor Recovery.
Review in JOR spine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Wearable Technologies for Gait Instability Rehabilitation: Mechanisms, Clinical Evidence, and Future Directions.Bioengineering (Basel, Switzerland) · 2026Review
- Spinal cord tissueoid transplantation combined with tail nerve electrical stimulation promotes the voluntary movement of paralyzed hindlimbs in rats with transected spinal cord injury.Materials today. Bio · 2026Article
- Feasibility and Safety of Combined Robot-Assisted Gait Training and Transcutaneous Spinal Cord Stimulation in Pediatric Incomplete Spinal Cord Injury: A Case Series.Children (Basel, Switzerland) · 2026Article
- The equilibrium point hypothesis revisited: why threshold control does not explain human movement.Experimental brain research · 2026Review
- Recovery in gait and posture: a network-based approach to the assessment of rehabilitation effectiveness after spinal cord injury.Frontiers in network physiology · 2026Article
- [Closed-loop regulation system for paralyzed lower limb joint movement based on electrical stimulation of spinal central pattern generator].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025Article
- State-of-the-Art in Robotic Rehabilitation for Spinal Cord Injury Patients: A Literature Review.Korean journal of neurotrauma · 2025Review
- Central Pattern Generators in Spinal Cord Injury: Mechanisms, Modulation, and Therapeutic Strategies for Motor Recovery.JOR spine · 2025Review
- Repetitive trans-spinal magnetic stimulation improves motor function in rats with spinal cord injury and is associated with upregulation of EphA4 signaling pathway proteins.Frontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Spinal cord injury (SCI) compromises the communication between the brain and spinal circuits involved in locomotion, resulting in severe motor dysfunction. However, currently available therapies have limited effectiveness in restoring motor function after SCI. Objective: Recent research has highlighted the importance of the central pattern generator (CPG), a spinal circuitry responsible for generating coordinated patterns of leg motor activity in the absence of brain-derived inputs, in locomotor recovery. Therefore, a highly promising approach for restorative treatment after SCI involves reactivating the CPG network to harness its rhythmic activity-generating capabilities. Various forms of neuromodulation, such as pharmacological agents, electrical stimulation, and light-based regulatory strategies, have been utilized for this purpose. Results: This review summarizes the organizational structure and functional characteristics of CPG networks, examines CPG alterations following SCI, and evaluates recent advances in neuromodulation strategies aimed at restoring motor function through CPG reactivation. Conclusions: This review also highlights existing challenges and outlines prospective directions for future research in the field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.