Evidence map›Paper›PMID 40791872›Full record

ArticleMolecular therapy. Nucleic acids2025

Partial correction of cystinuria type A in mice via kidney-targeted transposon delivery.

Lauren E Woodard, Richard C Welch, Anna Menshikh, Wentian Luo, Felisha M Williams, Jennifer L Peek, Feng Sha, Ruth Ann Veach, Aparna Kaja, Thomas M Beckermann and 2 more

Abstract read
In one paragraph

Article in Molecular therapy. Nucleic acids, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lauren E WoodardDepartment of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Richard C WelchDepartment of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Anna MenshikhDepartment of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Wentian LuoDepartment of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Felisha M WilliamsDepartment of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Jennifer L PeekMedical Scientist Training Program, Vanderbilt University, Nashville, TN 37232, USA.
Feng ShaDepartment of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Ruth Ann VeachDepartment of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Aparna KajaDepartment of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Thomas M BeckermannDepartment of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Talat Alp IkizlerDepartment of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Matthew H WilsonDepartment of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
Vanderbilt O'Brien Kidney Center - Core D - Clinical and Translational CoreP30DK114809 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZENT, ROY · 2017 to 2021
$5.9M
Medical Scientist Training ProgramT32GM152284 · NIGMS · VANDERBILT UNIVERSITY · PI Christopher S. Williams · 2024 to 2026
$4.8M
Novel cell therapy for sustained therapeutic protein delivery in vivoR01DK093660 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WILSON, MATTHEW H · 2012 to 2022
$3.4M
Next generation transposon vectors for genome engineeringR01EB033676 · NIBIB · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WILSON, MATTHEW H · 2022 to 2025
$2.0M
Proximal Tubule Targeted Gene Therapy for CystinuriaF30DK134046 · NIDDK · VANDERBILT UNIVERSITY · PI PEEK, JENNIFER · 2022 to 2025
$173k
BLRD VA I01 BX002190BLRD VA I01 BX004258BLRD VA I01 BX004845BLRD VA I21 BX006554BLRD VA IK2 BX002797NIBIB NIH HHS R01 EB033676NIDDK NIH HHS F30 DK134046NIDDK NIH HHS P30 DK114809NIDDK NIH HHS R01 DK093660NIGMS NIH HHS T32 GM007347NIGMS NIH HHS T32 GM152284
6 · The paper itself

Abstract

We used kidney-targeted, non-viral, transposon-mediated gene delivery to express the mouse

Indexed as

cystinuriagene therapyhydrodynamickidneyMT: Oligonucleotides: Therapies and ApplicationspiggyBacrBATSlc3a1transposon

Identifiers

PMID40791872
PMCPMC12337122

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.