Evidence map›Paper›PMID 40791846›Full record

ArticleIJID regions2025

Genomic analysis and molecular profiling of dengue viruses in Sabah, Malaysia during 2019-2020.

Mya Myat Ngwe Tun, Jecelyn Leaslie John, Takeshi Nabeshima, Abdul Marsudi Manah, Yuki Takamatsu, Takeshi Urano, Kouichi Morita, Kamruddin Ahmed

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IJID regions, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mya Myat Ngwe TunDepartment of Tropical Viral Vaccine Development, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.
Jecelyn Leaslie JohnBorneo Medical and Health Research Centre, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Sabah, Malaysia.
Takeshi NabeshimaDepartment of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.
Abdul Marsudi ManahSabah State Health Department, Sabah, Malaysia.
Yuki TakamatsuDepartment of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.
Takeshi UranoCenter for Vaccines and Therapeutic Antibodies for Emerging Infectious Diseases, Shimane University, Izumo, Japan.
Kouichi MoritaDepartment of Tropical Viral Vaccine Development, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.
Kamruddin AhmedBorneo Medical and Health Research Centre, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Sabah, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Limited information is available on the distribution of dengue virus (DENV) serotypes and genotypes in Borneo, particularly, in Sabah, because most studies have focused on Peninsular Malaysia. This study aimed to investigate the serologic and molecular epidemiologic characteristics of DENV in patients from Sabah. Methods: Serum samples were collected from febrile patients in Kota Kinabalu and Lahad Datu between 2019 and 2020 at the Kota Kinabalu Public Health Laboratory. We performed virus isolation, serological testing, viremia quantification, and complete genome sequencing. Results: Of 188 serum samples, 89 tested positive for DENV by quantitative reverse transcription-polymerase chain reaction: 20 DENV-1, 46 DENV-2, 20 DENV-3, and 1 DENV-4. A total of 38 viruses were successfully isolated. The isolates belonged to DENV-1 (genotypes I and IV), DENV-2 (cosmopolitan genotype) and DENV-3 (genotypes I and III). The phylogenetic analysis revealed close relationships with strains from Malaysia, Indonesia, and the Philippines. DENV-2 was the predominant serotype, whereas the highest viremia levels were observed in patients infected with DENV-3. Conclusions: To the best of our knowledge, this study provides the first detailed phylogenetic and complete genome analysis of DENV in Sabah. Continued molecular surveillance is essential to enhance our understanding of dengue transmission and support effective control strategies.

Indexed as

Complete genomeDengue virusPhylogenetic treeSabah

Identifiers

PMID40791846
PMCPMC12336003

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.