SynthesisFrontiers in physiology2025
Clinical effects of erythritol, glycine and trehalose as subgingival air-polishing powders on non-surgical periodontal treatment:a systematic review with meta-analysis of randomized controlled trials.
Synthesis in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Comparative analysis of low-abrasive powders on root surface roughness and substance loss: an ex vivo study.Clinical oral investigations · 2026Article
- Impact of Adjunctive Air-Polishing on Periodontal Status in Patients with Low Vitamin DJournal of clinical medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This study aimed to systematically compare the efficacy of erythritol, glycine, and trehalose as subgingival subgingival air polishing powders in non-surgical periodontal treatment (NSPT). Methods: Randomized controlled trials (RCTs) that met the inclusion and exclusion criteria were selected from PubMed, Embase, Web of Science, and Cochrane Library databases (up to August 2024). The sample size, treatment time, and outcome indicators including periodontal probing depth (PPD), clinical attachment level (CAL), and bleeding on probing (BOP) were extracted from the articles. Direct meta-analysis and network meta-analysis were performed by using " Results: Nine RCTs met the inclusion and exclusion criteria. A total of 462 patients were included in the study. For PPD, the network meta-analysis showed that there was no statistical significance in the cross-comparison of erythritol, glycine and trehalose. However, erythritol (SUCRA = 84.1) has an advantage over trehalose (SUCRA = 48.0) and glycine (SUCRA = 28.5) in reducing PPD. The results of direct meta-analysis showed that there was no significant statistical difference in the improvement of outcome indicators such as PPD, CAL and BOP by the three subgingival polishing powders. Conclusion: The recommended order of priority for the use of three subgingival subgingival air polishing powders is as follows: erythritol, trehalose, and glycine. Strenaths and limitaions of this study: We recommend the priority for the use of the three powders was as follows: erythritol, trehalose, and glycine.Limitations:limited number of RCTs made it difficult to draw a test for publication bias. Systematic Review Registration: identifier CRD42022366792.
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