Evidence map›Paper›PMID 40791811›Full record

ReviewKidney medicine2025

Assessing Caregiver Burden in Kidney Failure: A Systematic Review of Measurement Properties of Instruments.

Ravi Shankar, Eunice Wei Xin Lee, Nan Luo, Priyanka Khatri, Leanne Leong, Amartya Mukhopadhyay, Horng-Ruey Chua, Wei-Zhen Hong

Abstract readReview
In one paragraph

Review in Kidney medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ravi ShankarResearch and Innovation, Medical Affairs, Alexandra Hospital, Singapore.
Eunice Wei Xin LeeYong Loo Lin School of Medicine, National University of Singapore, Singapore.
Nan LuoSaw Swee Hock School of Public Health, National University of Singapore, Singapore.
Priyanka KhatriYong Loo Lin School of Medicine, National University of Singapore, Singapore.
Leanne LeongFast and Chronic Programmes, Alexandra Hospital, Singapore.
Amartya MukhopadhyayFast and Chronic Programmes, Alexandra Hospital, Singapore.
Horng-Ruey ChuaDivision of Nephrology, Department of Medicine, National University Hospital, Singapore.
Wei-Zhen HongFast and Chronic Programmes, Alexandra Hospital, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Caregiver burden in end-stage kidney disease requires assessment using validated instruments. This systematic review evaluated measurement properties of caregiver burden instruments in end-stage kidney disease using Consensus-Based Standards for the Selection of Health Measurement Instruments methodology. We searched 8 databases (PubMed, CINAHL, Embase, Web of Science, MEDLINE, Cochrane Library, Scopus, and PsycINFO) for studies evaluating measurement properties of caregiver burden instruments in caregivers of patients with kidney failure. The Consensus-Based Standards for the Selection of Health Measurement Instruments Risk of Bias checklist assessed methodological quality, and Grading of Recommendations Assessment, Development and Evaluation approach evaluated evidence quality. Twenty-four studies evaluating 21 distinct caregiver burden instruments were included. The Zarit Burden Interview, Caregiver Burden Scale, and Beck Depression Inventory were most frequently evaluated. Only a few instruments had high-quality evidence of sufficient content validity, internal consistency, test-retest reliability, and construct validity. Cross-cultural validity was assessed for only 9 instruments, with most rated as indeterminate owing to methodological limitations. No studies evaluated responsiveness to change over time. Quality of evidence was low to very low for most measurement properties, highlighting significant gaps in validation research. The Zarit Burden Interview, Caregiver Burden Scale, and Beck Depression Inventory show promising validity and reliability but require further testing. Rigorously conducted validation studies, involvement of caregivers of patients with kidney failure in content validation, and cross-cultural adaptations are priorities for optimizing burden assessment in this unique population.

Indexed as

caregiver burdenChronic kidney diseaseend-stage kidney diseasepatient-reported outcome measurespsychometrics

Identifiers

PMID40791811
PMCPMC12337670

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.