Evidence map›Paper›PMID 40791803›Full record

ArticleCurrent research in microbial sciences2025

Integrated metagenomics and transcriptomics analysis reveals pathways associated with oral periapical lesions formation and progression.

Alaa Muayad Altaie, Thenmozhi Venkatachalam, Kiran Patil, Farah Al-Marzooq, Surendra Singh Rawat, Ali Al Qabbani, Mohammed Amjed Alsaegh, Lakshman P Samaranayake, Sameh S M Soliman, Rifat Hamoudi

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Article in Current research in microbial sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alaa Muayad AltaieResearch Institute of Medical and Health Sciences, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.
Thenmozhi VenkatachalamDepartment of Biological Sciences, College of Medicine and Health Sciences, Khalifa University of Science and Technology, Abu Dhabi, P.O. Box 127788, United Arab Emirates.
Kiran PatilReference Laboratory for Infectious Disease, PureLab, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates.
Farah Al-MarzooqDepartment of Medical Microbiology and Immunology, College of Medicine and Health Sciences, UAE University, Al Ain, P.O. Box 15551, United Arab Emirates.
Surendra Singh RawatDepartment of Research and Graduate Studies, College of Medicine and Health Sciences, Mohammed Bin Rashid University, Dubai, P.O. Box 505055, United Arab Emirates.
Ali Al QabbaniDepartment of Oral and Craniofacial Health Sciences, College of Dental Medicine, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.
Mohammed Amjed AlsaeghDepartment of Oral and Craniofacial Health Sciences, College of Dental Medicine, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.
Lakshman P SamaranayakeDepartment of Oral Biosciences, Faculty of Dentistry, University of Hong Kong, Hong Kong.
Sameh S M SolimanResearch Institute of Medical and Health Sciences, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.
Rifat HamoudiResearch Institute of Medical and Health Sciences, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periapical abscesses, radicular cysts, and periapical granulomas are among the most frequently identified pathological lesions in the alveolar bone. Although many studies have investigated bacterial metagenomics in periapical abscesses, little is known about the genome mining of abundant bacteria in periapical lesions and its correlation to human transcriptome. This study aims to explore the enriched metabolic environment of periapical lesions associated with microbial diversity and their role in lesion progression. Bacterial DNA and human RNA were isolated from periapical lesions and healthy pulp tissue and sequenced using next-generation sequencing (NGS). The sequences of the most abundant bacteria were then analyzed to identify secondary metabolites, pathogenic proteins, and their associated metabolic pathways. The results revealed that

Indexed as

InflammationMetabolic pathwaysMetagenomicsPeriapical lesionsProteinsTranscriptomics

Identifiers

PMID40791803
PMCPMC12335967

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.