Evidence map›Paper›PMID 40791794›Full record

ArticleMaterials today. Bio2025

Curcumin-loaded nanoscale coordination polymers for ROS scavenging and anti-inflammatory therapy in atherosclerosis.

Song Ding, Wenyi Xu, Xueliang Liu, Zhinan Wu, Xinjie He, Yue Huang, Jiyuan Chen, Wei Yao, Huayuan Zhou, Yu Yang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Song DingDepartment of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Wenyi XuDepartment of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Xueliang LiuPunan Branch of Renji Hospital and Institute of Molecular Medicine (IMM), Shanghai Jiao Tong University School of Medicine, Shanghai, 200125, China.
Zhinan WuDepartment of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Xinjie HeDepartment of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Yue HuangDepartment of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Jiyuan ChenDepartment of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Wei YaoInstitute of Molecular Medicine (IMM), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Huayuan ZhouInstitute of Molecular Medicine (IMM), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Yu YangPunan Branch of Renji Hospital and Institute of Molecular Medicine (IMM), Shanghai Jiao Tong University School of Medicine, Shanghai, 200125, China.
Jun PuDepartment of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The progression of atherosclerosis (AS) is marked by escalating chronic inflammation and oxidative stress within the arterial wall, which heightens the risk of plaque rupture and subsequent acute ischemic cardiovascular and cerebrovascular events. Conventional anti-inflammatory and antioxidant therapies, however, are often limited by modest efficacy and potential side effects. Here, we synthesized iron-curcumin coordination polymers (Fe-Cur CPs) coordinated by trivalent iron ions and the natural product curcumin (Cur). These Fe-Cur CPs effectively scavenged excessive reactive oxygen species (ROS) in endothelial cells and macrophages, significantly reduced monocyte adhesion to activated endothelial cells, and attenuated the production of inflammatory factors by macrophages, thereby demonstrating potent antioxidant and anti-inflammatory properties. Additionally, they inhibited foam cell formation. In atherosclerotic

Indexed as

Anti-inflammationAtherosclerosisNanoscale coordination polymersROS scavenging

Identifiers

PMID40791794
PMCPMC12337887

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.