Evidence map›Paper›PMID 40791780›Full record

ReviewFrontiers in oral health2025

Membrane vesicles from Red Complex bacteria: key players in oral pathogenesis, immune disruption, systemic diseases, and therapeutic insights.

Venkatramanan Mahendrarajan, Huldah Pearlin Sarah Lazarus, Gothandam Kodiveri Muthukaliannan, Sheeja Varghese, Nalini Easwaran

Abstract readReview
In one paragraph

Review in Frontiers in oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Deciphering macrophage molecular responses toFrontiers in microbiology · 2026
    Article
  6. Article
  7. Clinical characteristics ofFrontiers in cellular and infection microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Venkatramanan MahendrarajanSchool of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, India.
Huldah Pearlin Sarah LazarusSchool of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, India.
Gothandam Kodiveri MuthukaliannanSchool of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, India.
Sheeja VargheseDepartment of Periodontics, Saveetha Institute of Medical and Technical Sciences, Chennai, India.
Nalini EaswaranSchool of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The oral cavity serves as a habitat for a diverse array of microorganisms, each performing distinct functions, thereby constituting a vibrant and intricate ecological community. The most common pathogenic bacteria in the oral ecosystem are the Red Complex group, which includes

Indexed as

outer membrane vesicles (OMVs)phytobioactivesprobioticsRed Complex bacteriasystemic diseases

Identifiers

PMID40791780
PMCPMC12336276

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.