ArticleFrontiers in oral health2025
Salivary microbiota profile in adult and children population according to active dentin caries: a metagenomic preliminary analysis.
Article in Frontiers in oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Tumor Biomarkers in Head and Neck Squamous Cell Carcinoma: From Etiology and Pathogenesis to Treatment Response-A Scoping Review.Biomedicines · 2026Review
- Oral microbiome signatures predict biological age and host health.Nature communications · 2026Article
- Diet-Oral Microbiota Interactions and Salivary Biomarkers of Nutritional Health: A Narrative Review.Nutrients · 2026Review
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Authors and funding
7 authors.
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Abstract
Objectives: The aim of this study was to investigate the relationship between active dentin caries (ADC), salivary biochemical parameters, and salivary microbiota composition in Spanish children and adults. Methods: Saliva samples were collected from 80 subjects (40 adults and 40 children) divided between ADC and non-ADC. Salivary biochemical determination was performed by analysing total protein content (TPC) and total antioxidant activity (TAC) in saliva supernatants. DNA was obtained from the pellet of saliva samples using the Bacterial DNA kit and analysed with the Illumina NextSeq platform from all participants. Alpha diversity (Chao, Observed Features, Shannon and Simpson indices) and beta diversity (PCoA plot and PERMANOVA procedure) were analysed. In addition, Linear Discriminant Analysis Effect Size (LEfSe) was used to identify differential taxa between groups. All statistical analysis were performed with a 95% confidence level ( Results: No significant associations were found between ADC and salivary biochemical markers in either the adult or pediatric age group, suggesting that these parameters alone may not sufficiently reflect cariogenic activity. Microbiota analysis at the phylum level did not show significant correlations with ADC; however, distinct associations appeared at the genus and species levels. In adults, several genera ( Conclusions: Overall, these findings highlight a stronger and more diverse association between salivary microbiota and caries in adults compared to children. These results underscore the importance of age-specific microbial signatures in the aetiology of dental caries. The obtained differences suggest that caries development in adults may involve broader dysbiosis involving proteolytic and anaerobic organisms in addition to acidogenic species.
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