Evidence map›Paper›PMID 40791723›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Antibody responses to SG6, AgSAP, and SAMSP1 following Anopheline salivary exposure.

Robert J Williams, Brian D Swinehart, Selma Abouneameh, Isaack J Rutha, Dominick C Msolo, Brian Tarimo, Erol Fikrig, Derrick Mathias, Billy Ngasala, Yu-Min Chuang and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Robert J WilliamsInstitute of Global Health and Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, NC USA.ORCID 0000-0003-3099-1143
Brian D SwinehartInstitute of Global Health and Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, NC USA.
Selma AbouneamehSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, Connecticut, USA.
Isaack J RuthaDepartment of Parasitology and Medical Entomology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Dominick C MsoloDepartment of Parasitology and Medical Entomology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Brian TarimoVector Immunity and Transmission Biology Unit, Department of Environmental Health and Ecological Sciences, Ifakara Health Institute-Bagamoyo Office, P.O. Box 74, Bagamoyo, Coast Region, 61301, Tanzania.
Erol FikrigSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, Connecticut, USA.
Derrick MathiasDepartment of Entomology & Nematology, Florida Medical Entomology Laboratory, Institute of Food and Agricultural Sciences, University of Florida, Vero Beach, FL 32962, USA.
Billy NgasalaDepartment of Parasitology and Medical Entomology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Yu-Min ChuangSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, Connecticut, USA.
Jessica T LinInstitute of Global Health and Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, NC USA.

Funding

Measuring the transmissibility of recurrent parasitemias that arise following artemisinin-based combination therapyR21AI180675 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIN, JESSICA · 2024 to 2025
$465k
Plasmodium ovale hypnozoite development and relapse: a coordinated in vivo in vitro studyR21AI152260 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ADAMS, JOHN H, LIN, JESSICA · 2021 to 2022
$418k
NIAID NIH HHS R21 AI152260NIAID NIH HHS R21 AI180675
6 · The paper itself

Abstract

Background: Current methods to determine exposure to malaria-infected mosquitoes via entomologic investigations are technically challenging and can be inaccurate in low transmission settings. Antibody responses to mosquito salivary antigens (MSA) like gSG6-P1 have been used as biomarkers of exposure to Methods: This study investigates two novel Results: GSG6-P1, AgSAP, and SAMSP1 levels increased in mice at eight weeks after weekly mosquito feedings. However, human gSG6-P1 and AgSAP levels were paradoxically lower four weeks after direct skin feeding assays. SAMSP1 was the only MSA that induced a significantly higher humoral response during the rainy season, suggesting that it may be a more reliable biomarker for vector exposure in regions with multiple Anopheles species. Conclusions: Mosquito salivary antigens associated with

Indexed as

AgSAPAnophelesbiomarkermalariamosquito feedingMosquito salivary antigenPlasmodium falciparumSAMSP1SG6vector exposure

Identifiers

PMID40791723
PMCPMC12338902

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.