Evidence map›Paper›PMID 40791659›Full record

ArticleFrontiers in molecular biosciences2025

Decreased brain-derived neurotrophic factor expression in chronic kidney disease: integrated clinical and experimental evidence.

Juan Chen, Lili Fu, Mengjin Li, Kun Xie, Xinming Li, Xu-Jie Zhou, Li Yang, Liming Zhang, Cheng Xue, Zhiguo Mao

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular biosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Juan Chen *Department of Nephrology, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University, Second Military Medical University, Shanghai, China.
Lili Fu *Department of Nephrology, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University, Second Military Medical University, Shanghai, China.
Mengjin Li *Department of Nephrology, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University, Second Military Medical University, Shanghai, China.
Kun XieDepartment of Nephrology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China.
Xinming LiDepartment of Nephrology, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University, Second Military Medical University, Shanghai, China.
Xu-Jie ZhouKey Laboratory of Renal Disease, Peking University First Hospital, Renal Division, Ministry of Health of China, Institute of Nephrology, Peking University, Beijing, China.
Li YangKey Laboratory of Renal Disease, Peking University First Hospital, Renal Division, Ministry of Health of China, Institute of Nephrology, Peking University, Beijing, China.
Liming ZhangDepartment of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, GA, United States.
Cheng XueDepartment of Nephrology, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University, Second Military Medical University, Shanghai, China.
Zhiguo MaoDepartment of Nephrology, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University, Second Military Medical University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chronic kidney disease (CKD) is a progressive disorder characterized by declining renal function and systemic metabolic disturbances. Brain-derived neurotrophic factor (BDNF), a key member of the neurotrophic family, plays critical roles in neuronal function and muscular metabolism. However, the evidence and regulatory mechanisms underlying decreased BDNF levels in CKD remain inconclusive. Methods: This study systematically evaluated circulating BDNF alterations in CKD patients through a meta-analysis of clinical studies involving 1,549 participants, complemented by experimental validation in unilateral ureteral obstruction (UUO) mice and single-cell transcriptomic database analysis to investigate tissue-specific BDNF protein expression and regulatory patterns. Results: Meta-analysis confirmed significantly reduced circulating BDNF in CKD patients (WMD = -0.62 ng/mL, 95% CI [-0.98, -0.25], Conclusion: This study integrated meta-analysis, murine model validation, and single-cell transcriptomic profiling to demonstrate a significant reduction of BDNF in CKD. Furthermore, renal BDNF expression decreased locally, predominantly originating from proximal tubule cells, macrophages, and podocytes, possibly epigenetically inhibited by the upregulation of lnc RNA

Indexed as

brain-derived neurotrophic factorchronic kidney diseasemeta-analysissingle-cell transcriptomicsWestern blot

Identifiers

PMID40791659
PMCPMC12336020

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.