ArticleAmerican journal of ophthalmology case reports2025
Ocular post-transplant lymphoproliferative disorder after keratoplasty.
Article in American journal of ophthalmology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Epstein-Barr virus associated post-transplantation lymphoproliferative disorders (PTLD) is a common condition after solid-organ or allogeneic hematopoietic stem-cell transplants. But ocular involvement after keratoplasty remains a rare finding, and can be easily misdiagnosed. Observations: We report a case of a 59-year-old man who presented with masquerade uveitis of right eye 4 months post penetrating keratoplasty and was ultimately diagnosed with ocular PTLD. The diagnosis relied on the presence of Epstein-Barr virus DNA in aqueous sample and iris specimens showed the presence of a B cell clone. The ocular condition was in complete remission after 15 intravitreal injections of methotrexate. Conclusions and Importance: Local immunosuppression after keratoplasty can lead to ocular PTLD. Detection of Epstein-Barr virus DNA in intraocular fluid and tissue or cytological biopsy could help confirm the diagnosis.
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