Evidence map›Paper›PMID 40791596›Full record

ArticleFrontiers in immunology2025

Exploring the mycobiota in multiple sclerosis: its influence on disease development and progression.

Ane Otaegui-Chivite, Miriam Gorostidi-Aicua, Laura Martins-Almeida, Ainhoa Alberro, Leire Romarate, Idoia Mendiburu, Amaya Álvarez de Arcaya, Maialen Arruti, Tamara Castillo-Triviño, David Otaegui and 1 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ane Otaegui-ChiviteGroup of Neuroimmunilogy, Biogipuzkoa Health Research Institute, San Sebastián, Spain.
Miriam Gorostidi-AicuaGroup of Neuroimmunilogy, Biogipuzkoa Health Research Institute, San Sebastián, Spain.
Laura Martins-AlmeidaGroup of Neuroimmunilogy, Biogipuzkoa Health Research Institute, San Sebastián, Spain.
Ainhoa AlberroGroup of Neuroimmunilogy, Biogipuzkoa Health Research Institute, San Sebastián, Spain.
Leire RomarateGroup of Neuroimmunilogy, Biogipuzkoa Health Research Institute, San Sebastián, Spain.
Idoia MendiburuGroup of Neuroimmunilogy, Biogipuzkoa Health Research Institute, San Sebastián, Spain.
Amaya Álvarez de ArcayaNeurology Department, Hospital Universitario Araba, Osakidetza Basque Health Service, Vitoria, Spain.
Maialen ArrutiGroup of Neuroimmunilogy, Biogipuzkoa Health Research Institute, San Sebastián, Spain.
Tamara Castillo-TriviñoGroup of Neuroimmunilogy, Biogipuzkoa Health Research Institute, San Sebastián, Spain.
David Otaegui *Group of Neuroimmunilogy, Biogipuzkoa Health Research Institute, San Sebastián, Spain.
Laura Moles *Group of Neuroimmunilogy, Biogipuzkoa Health Research Institute, San Sebastián, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Multiple sclerosis (MS) is a complex immune-mediated disorder influenced by genetic, environmental, and microbial factors. Recent research has focused on the gut microbiota's role in MS, yet limited studies have examined the fungal microbiota (mycobiota) in this context. Methods: In this study, we characterized the gut mycobiota of individuals with MS from the Basque Country, identifying specific fungal taxa associated with MS risk factors, clinical severity, and dietary patterns. Results: Our results revealed higher fungal diversity and richness in MS patients compared to controls, with significant enrichment of certain genera, including Conclusion: These findings provide new insights into the fungal component of the gut microbiota in MS and underscore its potential role in disease pathogenesis and progression. Our work suggests that fungal biomarkers, together with genetic and dietary factors, may help refine our understanding of MS and support the development of mycobiota-targeted therapies.

Indexed as

FungiGastrointestinal MicrobiomeMultiple SclerosisMycobiomeAdultBiomarkersDisease ProgressionFemaleHLA-DRB1 ChainsHumansMaleMiddle AgedBiomarkersHLA-DRB1 ChainscalprotectinchitotriosidaseHLA-DRB1*1501multiple sclerosismycobiome

Identifiers

PMID40791596
PMCPMC12338046

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.