Evidence map›Paper›PMID 40791583›Full record

ArticleFrontiers in immunology2025

Conserved function of bat TBK1 in activating innate immunity against RNA viruses: insights into the innate immune response in bats.

Qiuju Liu, Qi Shao, Caixia Xu, Chao Liu, Shuhan Li, Jie Wang, Xia Liu, Kehui Zhang, Yaxian Yan, Jianhe Sun and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qiuju LiuShanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Qi ShaoShanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Caixia XuShanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Chao LiuKey Laboratory of Veterinary Pathobiology and Disease Control, College of Animal Science and Technology, Anhui Agricultural University, Hefei, Anhui, China.
Shuhan LiShandong Provincial Key Laboratory of Zoonoses, Sino-German Cooperative Research Centre for Zoonosis of Animal Origin of Shandong Province, College of Veterinary Medicine, Shandong Agricultural University, Shandong, China.
Jie WangShanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Xia LiuShanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Kehui ZhangShanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Yaxian YanShanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Jianhe SunShanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Yuqiang ChengShanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bats exhibit unique abilities to coexist with viruses asymptomatically, setting them apart among mammals. The innate immune system serves as the primary defense against pathogens. As a crucial central node protein in this system, TANK binding kinase 1(TBK1) can receive signals from multiple pattern recognition receptors (PRRs), and then promote the production of Type I interferon (IFN I) and inflammatory factors. Despite its importance, how TBK1 works in bats remains poorly understood. Here, through bioinformatics analysis, TBK1 was found to exhibit a high sequence conservation across species. Overexpression of bat TBK1 significantly upregulated IFNβ expression, and then inhibited viral replication. Co-expression of bat TBK1 with bat IRF1/3/7 can facilitate the upregulation of IFNβ mediated by bat TBK1, implying the activation signals potentially can be transmitted from bat TBK1 to IRF1/3/7, and then promote IFNβ production. Structurally, protein kinase domain (PKD), ubiquitin-like domain (ULD), and coiled-coil domain 1 (CCD1) are essential domains for bat TBK1 to function normally. In summary, this study elucidated bat TBK1 has a conserved ability to activate bat antiviral innate immunity.

Indexed as

ChiropteraImmunity, InnateProtein Serine-Threonine KinasesRNA VirusesRNA Virus InfectionsAnimalsHumansInterferon-betaSignal TransductionVirus ReplicationInterferon-betaProtein Serine-Threonine KinasesBATIFNβinnate immunityTBK1virus

Identifiers

PMID40791583
PMCPMC12336183

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.