Evidence map›Paper›PMID 40791546›Full record

ArticlebioRxiv : the preprint server for biology2025

Differential expression of a disease-associated

McKenna B DeFoer, Ahmed M Mostafa, Andrea J Hartlerode, Steven K Orban, Keegan McDonough, Sophie Quirk, Brianna K L Ferguson, David O Ferguson, JoAnn M Sekiguchi

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

McKenna B DeFoerDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA.
Ahmed M MostafaDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Andrea J HartlerodeDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA.
Steven K OrbanDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Keegan McDonoughDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA.
Sophie QuirkDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA.
Brianna K L FergusonDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA.
David O FergusonDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
JoAnn M SekiguchiDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0002-7178-4258

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eric R. Fearon · 1988 to 2026
$178.2M
NCI NIH HHS P30 CA046592
6 · The paper itself

Abstract

The MRE11 DNA nuclease plays central roles in the repair of DNA double-strand breaks (DSBs) as a core component of the heterotrimeric MRE11/RAD50/NBS1 (MRN) complex. MRN localizes to chromosomal DSBs and recruits and activates the apical DSB repair protein kinase, ATM, which phosphorylates downstream substrates to elicit cellular DNA damage responses. Pathogenic variants in

Identifiers

PMID40791546
PMCPMC12338695

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.