Evidence map›Paper›PMID 40791542›Full record

ArticlebioRxiv : the preprint server for biology2025

Fold first, ask later: structure-informed function annotation of

Hannelore Longin, George Bouras, Susanna R Grigson, Robert A Edwards, Hanne Hendrix, Rob Lavigne, Vera van Noort

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hannelore LonginComputational Systems Biology, Department of Molecular and Microbial Systems, KU Leuven, Heverlee, Belgium.ORCID 0000-0001-8524-5768
George BourasAdelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia.ORCID 0000-0002-5885-4186
Susanna R GrigsonFlinders Accelerator for Microbiome Exploration, Flinders University, Adelaide, Australia.ORCID 0000-0003-4738-3451
Robert A EdwardsFlinders Accelerator for Microbiome Exploration, Flinders University, Adelaide, Australia.ORCID 0000-0001-8383-8949
Hanne HendrixLaboratory of Gene Technology, Department of Biosystems, KU Leuven, Heverlee, Belgium.ORCID 0000-0002-5432-9456
Rob LavigneLaboratory of Gene Technology, Department of Biosystems, KU Leuven, Heverlee, Belgium.ORCID 0000-0001-7377-1314
Vera van NoortComputational Systems Biology, Department of Molecular and Microbial Systems, KU Leuven, Heverlee, Belgium.ORCID 0000-0002-8436-6602

Funding

Computational and Experimental Resources for Virome Analysis in Inflammatory Bowel Disease (CERVAID)RC2DK116713 · NIDDK · WASHINGTON UNIVERSITY · PI WANG, DAVID · 2019 to 2023
$8.9M
NIDDK NIH HHS RC2 DK116713
6 · The paper itself

Abstract

Phages, the viruses of bacteria, harbor an incredibly diverse repertoire of proteins capable of manipulating their bacterial hosts, inspiring many medical and biotechnological applications. However, to date, only a limited subset of that repertoire can be exploited, due to the difficulties in functionally elucidating these proteins. In this study, we investigated several structure-informed approaches to annotate hypothetical proteins from

Indexed as

AlphaFoldPhageprotein functionPseudomonasviral dark matter

Identifiers

PMID40791542
PMCPMC12338637

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.