Evidence map›Paper›PMID 40791538›Full record

ArticlebioRxiv : the preprint server for biology2025

Hypoxia-Induced Metabolic Reprogramming and Markings of Cell Fate in Concentric Arterial Hypertrophy.

Lucas Ferreira de Almeida, Jason P Smith, Manako Yamaguchi, Silvia Medrano, Alexandre Martini, Daisuke Matsuoka, Zuzanna J Juśkiewicz, Brant E Isakson, Hiroki Yamaguchi, Dilza Trevisan Silva and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lucas Ferreira de AlmeidaChild Health Research Center Department of Pediatrics, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0002-5731-1219
Jason P SmithChild Health Research Center Department of Pediatrics, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0002-2688-0988
Manako YamaguchiChild Health Research Center Department of Pediatrics, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0002-2880-9165
Silvia MedranoChild Health Research Center Department of Pediatrics, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0002-8516-0788
Alexandre MartiniChild Health Research Center Department of Pediatrics, University of Virginia, Charlottesville, VA, USA.
Daisuke MatsuokaChild Health Research Center Department of Pediatrics, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0002-2164-0555
Zuzanna J JuśkiewiczRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, USA.
Brant E IsaksonRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID 0000-0002-7692-6294
Hiroki YamaguchiChild Health Research Center Department of Pediatrics, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0003-2409-7401
Dilza Trevisan SilvaUniversidade Positivo, Curitiba, Brazil.ORCID 0000-0002-6519-346X
Thomas WagamonChild Health Research Center Department of Pediatrics, University of Virginia, Charlottesville, VA, USA.
Maria Luisa S Sequeira-LopezChild Health Research Center Department of Pediatrics, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0002-4459-7940
R Ariel GomezChild Health Research Center Department of Pediatrics, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0002-5124-8255

Funding

Single-Cell Epigenomics, Transcriptomics, and Bioinformatics CoreP50DK096373 · NIDDK · UNIVERSITY OF VIRGINIA · PI ROBERTO Ariel GOMEZ · 2012 to 2026
$13.8M
NIDDK NIH HHS P50 DK096373
6 · The paper itself

Abstract

Chronic inhibition of the renin-angiotensin system (RAS), while widely used to treat hypertension, can lead to an underrecognized form of vascular disease marked by concentric arteriolar and arterial hypertrophy (CAAH). Here, using two lineage-traced mouse models of genetic renin deletion and sustained RAS blockade, we uncover a pathogenic cascade initiated by renin-lineage cell fate reprogramming. Loss of endocrine identity and transformation of smooth muscle cells drives a shift toward a fibrotic, inflammatory, and secretory phenotype that remodels the extracellular matrix and promotes vascular thickening and luminal narrowing. Integrated transcriptomic, proteomic, and metabolomic profiling revealed a hypoxia-linked metabolic switch-characterized by succinate accumulation and NAD

Identifiers

PMID40791538
PMCPMC12338582

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.