Evidence map›Paper›PMID 40791535›Full record

ArticlebioRxiv : the preprint server for biology2025

Functional Comparison to Ezh2 Reveals PRC2-Independent Functions of Jarid2 in Hematopoietic Stem Cell Lineage Commitment.

Hassan Bjeije, Wentao Han, Nancy Issa, Aishwarya Krishnan, Infencia Xavier Raj, Jason Arand, Yanan Li, Wei Yang, Jeffrey A Magee, Grant A Challen

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Hassan BjeijeDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA, 63110.
Wentao HanDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA, 63110.
Nancy IssaDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA, 63110.
Aishwarya KrishnanDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA, 63110.
Infencia Xavier RajDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA, 63110.
Jason ArandDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA, 63110.
Yanan LiDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA, 63110.
Wei YangDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA, 63110.
Jeffrey A MageeDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA, 63110.
Grant A ChallenDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA, 63110.ORCID 0000-0003-4669-8814

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI David G DeNardo · 2001 to 2026
$128.0M
The role of Kmt2c/MLL3 in hematopoietic stem cell self-renewal, commitment and exhaustionR01HL152180 · NHLBI · WASHINGTON UNIVERSITY · PI Jeffrey Alan Magee · 2020 to 2026
$3.0M
Inflammatory Stress Promotes Clonal Expansion of DNMT3A-mutant HSCsR01DK124883 · NIDDK · WASHINGTON UNIVERSITY · PI Grant Anthony Challen · 2020 to 2026
$2.5M
JAK/STAT signaling in the pathogenesis of DNMT3A mutant T-ALLR01CA236819 · NCI · WASHINGTON UNIVERSITY · PI CHALLEN, GRANT ANTHONY · 2020 to 2024
$1.8M
Functions of JARID2 in Normal and Neoplastic HematopoiesisR01HL147978 · NHLBI · WASHINGTON UNIVERSITY · PI CHALLEN, GRANT ANTHONY · 2019 to 2022
$1.6M
NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA236819NHLBI NIH HHS R01 HL147978NHLBI NIH HHS R01 HL152180NIDDK NIH HHS R01 DK124883
6 · The paper itself

Abstract

Previous studies showed the Polycomb Repressive Complex 2 (PRC2) co-factor Jarid2 represses self-renewal transcriptional networks in mouse multipotent progenitor cells (MPPs). But only a fraction of de-repressed HSC-specific genes were associated with loss of H3K27me3, implying Jarid2 may have non-canonical (PRC2-indpendent) in hematopoiesis. Here we sought to delineate any PRC2-independnent functions by comparing stem and progenitor cells genetically deficient for either

Identifiers

PMID40791535
PMCPMC12338735

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.