Evidence map›Paper›PMID 40791527›Full record

ArticlebioRxiv : the preprint server for biology2025

Dynamic extracellular interactions with AMPA receptors.

Hana Goldschmidt Merrion, Casey N Barber, Santosh S Renuse, Jevon Cutler, Simion Kreimer, Alexei M Bygrave, David J Meyers, W Dylan Hale, Akhilesh Pandey, Richard L Huganir

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Hana Goldschmidt MerrionSolomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.ORCID 0000-0002-5676-366X
Casey N BarberSolomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.ORCID 0009-0005-4310-6395
Santosh S RenuseMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.ORCID 0000-0002-4051-5637
Jevon CutlerMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.ORCID 0000-0002-3402-4292
Simion KreimerDepartment of Biological Chemistry, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.ORCID 0000-0001-6627-3771
Alexei M BygraveSolomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.ORCID 0000-0003-2291-923X
David J MeyersDepartment of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.ORCID 0000-0002-7010-6930
W Dylan HaleSolomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.ORCID 0000-0002-1492-0735
Akhilesh PandeyMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.ORCID 0000-0001-9943-6127
Richard L HuganirSolomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.ORCID 0000-0001-9783-5183

Funding

The Dynamic AMPA Receptor Interactome During Plasticity and LearningR37NS036715 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Richard L Huganir · 2022 to 2026
$3.2M
Molecular basis of glutamatergic synapse function in inhibitory interneuronsR00MH124920 · NIMH · TUFTS UNIVERSITY BOSTON · PI BYGRAVE, ALEXEI MANSFIELD · 2022 to 2024
$735k
Structure-guided functional analysis of GluA4-NPTX2 interaction during PVIN homeostatic scalingK99MH132811 · NIMH · JOHNS HOPKINS UNIVERSITY · PI HALE, WILLIAM DYLAN · 2023 to 2024
$206k
Proteomic mining of intra- and extracellular proteins that modulate AMPA receptor functionF32NS098946 · NINDS · JOHNS HOPKINS UNIVERSITY · PI GOLDSCHMIDT, HANA L · 2017 to 2019
$184k
NIMH NIH HHS K99 MH132811NIMH NIH HHS R00 MH124920NINDS NIH HHS F32 NS098946NINDS NIH HHS R37 NS036715
6 · The paper itself

Abstract

Synaptic plasticity in the central nervous system enables the encoding, storing, and integrating new information. AMPA-type glutamate receptors (AMPARs) are ligand-gated ion channels that mediate most fast excitatory synaptic transmission in the brain, and plasticity of AMPARs signaling underlies the long-lasting changes in synaptic efficacy and strength important for learning and memory.

Indexed as

AMPA receptorextracellularIgLONproximity proteomicssynaptic plasticity

Identifiers

PMID40791527
PMCPMC12338540

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.