Evidence map›Paper›PMID 40791514›Full record

ArticlebioRxiv : the preprint server for biology2025

Cytochrome

Anthony W DeMartino, Onaje Cunningham, Saumika Mulluri, Deandra Cassel, Megan Hutar, Lawrence Ji, Efthimios A Deligiannidis, Stefan J Kaliszuk, Xueyin N Huang, Qin Tong and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Anthony W DeMartinoHeart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261.ORCID 0000-0001-5303-5758
Onaje CunninghamHeart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261.
Saumika MulluriHeart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261.
Deandra CasselHeart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261.
Megan HutarHeart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261.
Lawrence JiHeart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261.
Efthimios A DeligiannidisHeart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261.ORCID 0009-0005-2597-6258
Stefan J KaliszukHeart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261.
Xueyin N HuangHeart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261.
Qin TongHeart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261.
Yvette Y YienHeart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261.ORCID 0000-0001-6451-9272
Matthew R DentHeart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261.ORCID 0000-0002-7704-4867
Jason J RoseDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0003-1347-9148
Jesús TejeroHeart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261.ORCID 0000-0003-3245-9978

Funding

Antidote for inhaled CO poisoning based on mutationally engineered neuroglobinR01HL125886 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Mark T Gladwin, Jesus Tejero Bravo · 2015 to 2026
$7.9M
Translational Pulmonary Vascular BiologyT32HL110849 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sruti Shiva · 2012 to 2026
$5.0M
Regulation of heme synthesis by mitochondrial proteinsR35GM133560 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YIEN, YVETTE Y · 2019 to 2023
$2.1M
Optimization of a carbon monoxide (CO) sensing hemoprotein for applications as an antidote for CO poisoning and a biosensor for CO detection in living cellsK99HL168224 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DENT, MATTHEW RYAN · 2023 to 2024
$326k
Development of a carbon monoxide scavenging hemoprotein as a novel antidotal therapy to treat inhaled CO poisoningF32HL162381 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DENT, MATTHEW RYAN · 2022 to 2022
$77k
NHLBI NIH HHS F32 HL162381NHLBI NIH HHS K99 HL168224NHLBI NIH HHS R01 HL125886NHLBI NIH HHS T32 HL110849NIGMS NIH HHS R35 GM133560
6 · The paper itself

Abstract

Cytoglobin and Neuroglobin are heme-containing proteins expressed in most vertebrates, including mammals, with still not completely defined physiological roles. Most of the putative functions of cytoglobin/neuroglobin, such as oxygen binding or nitric oxide dioxygenation, rely on the heme iron being in the ferrous (Fe

Indexed as

Cytochrome b5 reductase 3Cytochrome b5 reductase 4CytoglobinNeuroglobin

Identifiers

PMID40791514
PMCPMC12338690

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.