Evidence map›Paper›PMID 40791513›Full record

ArticlebioRxiv : the preprint server for biology2025

Comprehensively Testing the Function of Missense Variation in the

Daniel Zimmerman, Atina Cote, Warren van Loggerenberg, Marinella Gebbia, Nishka Kishore, Jochen Weile, Roujia Li, Chloe Reno, Ashley Pl Marsh, Felicia Hernandez and 14 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Daniel ZimmermanThe Donnelly Centre, University of Toronto, Toronto, ON, Canada.ORCID 0009-0003-2264-6769
Atina CoteThe Donnelly Centre, University of Toronto, Toronto, ON, Canada.
Warren van LoggerenbergThe Donnelly Centre, University of Toronto, Toronto, ON, Canada.
Marinella GebbiaThe Donnelly Centre, University of Toronto, Toronto, ON, Canada.
Nishka KishoreThe Donnelly Centre, University of Toronto, Toronto, ON, Canada.
Jochen WeileThe Donnelly Centre, University of Toronto, Toronto, ON, Canada.ORCID 0000-0003-1628-9390
Roujia LiThe Donnelly Centre, University of Toronto, Toronto, ON, Canada.
Chloe RenoThe Donnelly Centre, University of Toronto, Toronto, ON, Canada.
Ashley Pl MarshAmbry Genetics, Aliso Viejo, CA 92656, USA.
Felicia HernandezAmbry Genetics, Aliso Viejo, CA 92656, USA.
Preksha ShahagadkarTango Therapeutics, Boston, USA.
Lauren GroveTango Therapeutics, Boston, USA.
Samuel R MeierTango Therapeutics, Boston, USA.
Hsin-Jung WuTango Therapeutics, Boston, USA.
Silvia FenoglioTango Therapeutics, Boston, USA.
Leanne AhronianTango Therapeutics, Boston, USA.
Teng TengTango Therapeutics, Boston, USA.
Andrew J WatersWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
David SewardDepartment of Pathology, University of Vermont, Burlington, 5445, VT, USA.
Mikko TaipaleThe Donnelly Centre, University of Toronto, Toronto, ON, Canada.ORCID 0000-0003-3811-1761
Melyssa AronsonZane Cohen Centre for Digestive Diseases, Sinai Health, ON, Canada.
Marcy E RichardsonAmbry Genetics, Aliso Viejo, CA 92656, USA.ORCID 0000-0002-4626-4920
David J AdamsWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Frederick P RothThe Donnelly Centre, University of Toronto, Toronto, ON, Canada.

Funding

Technology to understand genetic variant effects in contextRM1HG010461 · NHGRI · UNIVERSITY OF WASHINGTON · PI Douglas M Fowler, Bruce Colston Trapnell · 2019 to 2026
$18.9M
Molecular phenotyping of ~100,000 coding variants across Mendelian disease genesUM1HG011989 · NHGRI · DANA-FARBER CANCER INST · PI Marc Vidal · 2021 to 2026
$9.9M
Systematically mapping variant effects for cardiovascular genesR01HL164675 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ASHLEY, EUAN A, RODEN, DAN M · 2022 to 2025
$8.1M
NHGRI NIH HHS RM1 HG010461NHGRI NIH HHS UM1 HG011989NHLBI NIH HHS R01 HL164675
6 · The paper itself

Abstract

The tumor suppressor gene

Identifiers

PMID40791513
PMCPMC12338614

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.