Evidence map›Paper›PMID 40791511›Full record

ArticlebioRxiv : the preprint server for biology2025

Sensory neurostimulation promotes stress resilience with frequency-specificity.

Tina C Franklin, Sara Bitarafan, Alexia T King, Matthew Goodson, Catherine Rutledge, Tarini Gajelli, Ashley Prichard, Hector Zepeda, Nancy Kye, Steven A Sloan and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tina C FranklinWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA.ORCID 0000-0001-5958-3499
Sara BitarafanParker H. Petit Institute for Bioengineering, Georgia Institute of Technology, Atlanta, GA, USA.ORCID 0000-0003-4584-1420
Alexia T KingDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA.
Matthew GoodsonWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA.ORCID 0000-0003-1282-8238
Catherine RutledgeWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA.ORCID 0009-0009-7161-1814
Tarini GajelliWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA.ORCID 0009-0009-5597-5896
Ashley PrichardWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA.ORCID 0000-0001-7666-1444
Hector ZepedaWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA.ORCID 0000-0001-8640-7386
Nancy KyeWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA.ORCID 0009-0004-6186-1872
Steven A SloanDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA.ORCID 0000-0001-7769-7684
Levi WoodWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA.ORCID 0000-0002-4248-0888
Annabelle C SingerWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA.ORCID 0000-0001-6003-0488

Funding

The Goizueta Alzheimer's Disease Research CenterP30AG066511 · NIA · EMORY UNIVERSITY · PI ALLAN I LEVEY · 2020 to 2026
$29.0M
Molecular Drivers of Human GliogenesisR01MH125956 · NIMH · EMORY UNIVERSITY · PI SLOAN, STEVEN A · 2021 to 2025
$3.0M
Non-Invasive Methods to Drive Neural Activity with Millisecond Precision and to Recruit the Brain’s Immune CellsR01NS109226 · NINDS · GEORGIA INSTITUTE OF TECHNOLOGY · PI Annabelle Catherine Singer · 2018 to 2026
$2.7M
Hippocampal interneurons in novel memory formation in health and Alzheimer's diseaseRF1AG078736 · NIA · GEORGIA INSTITUTE OF TECHNOLOGY · PI SINGER, ANNABELLE CATHERINE · 2022 to 2025
$2.5M
Gamma Sensory Flicker as an Early Intervention for Alzheimer’s Disease: Mechanisms and Protective EffectsRF1NS109226 · NINDS · GEORGIA INSTITUTE OF TECHNOLOGY · PI SINGER, ANNABELLE CATHERINE · 2023 to 2024
$2.2M
NIA NIH HHS P30 AG066511NIA NIH HHS RF1 AG078736NIMH NIH HHS R01 MH125956NINDS NIH HHS R01 NS109226NINDS NIH HHS RF1 NS109226
6 · The paper itself

Abstract

Chronic stress is a major risk factor for neuropsychiatric disorders, acting via increased neuroinflammation and disrupted synaptic plasticity. While non-invasive visual or audiovisual neurostimulation (AV flicker) at 40Hz has been shown to modulate brain immune signaling and improve cognitive performance in mouse models of Alzheimer's disease, its effects in the context of stress remain unknown. Here we show that AV flicker protects against stress-induced behavioral, microglial, astrocytic, and synaptic changes in a sex- and frequency-specific manner. Male and female mice underwent 28 days of chronic unpredictable stress with concomitant daily AV flicker exposure at 10Hz, 20Hz, or 40Hz. Stress-induced behaviors were most effectively mitigated by 10Hz AV flicker in males and 40Hz AV flicker in females. In the medial prefrontal cortex, AV flicker normalized the balance of mature and immature dendritic spines and counteracted stress-induced molecular changes in neurons, microglia, and astrocytes, including in key neuropsychiatric risk genes. These findings show that frequency optimized AV flicker induces resilience to chronic stress.

Indexed as

AstrocytesAudiovisual sensory stimulationChronic stressDendritic spinesFlickerMedial prefrontal cortex (mPFC)MicrogliaNeuropsychiatric risk genesNon-invasive brain stimulationResilience

Identifiers

PMID40791511
PMCPMC12338667

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.