Evidence map›Paper›PMID 40791509›Full record

ArticlebioRxiv : the preprint server for biology2025

Does chlorotoxin target matrix metalloproteinase-2 in glioblastoma?

Eli Blaney, Meron Demeke, Seraphine Kamayirese, Louise Monga, Laura A Hansen, Charles R Watts, Sándor Lovas

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Eli BlaneyDepartment of Biomedical Sciences, School of Medicine, Creighton University, Omaha, NE 68178.ORCID 0000-0001-9956-2510
Meron DemekeDepartment of Biomedical Sciences, School of Medicine, Creighton University, Omaha, NE 68178.
Seraphine KamayireseDepartment of Biomedical Sciences, School of Medicine, Creighton University, Omaha, NE 68178.
Louise MongaDepartment of Biomedical Sciences, School of Medicine, Creighton University, Omaha, NE 68178.
Laura A HansenDepartment of Biomedical Sciences, School of Medicine, Creighton University, Omaha, NE 68178.
Charles R WattsDepartment of Neurosurgery, Park Nicollet, Methodist Hospital, St. Louis Park, MN 55426.ORCID 0000-0002-5011-487X
Sándor LovasDepartment of Biomedical Sciences, School of Medicine, Creighton University, Omaha, NE 68178.ORCID 0000-0002-5089-5186

Funding

Understanding the progression of hearing loss in an endolymphatic hydrops modelP20GM139762 · NIGMS · CREIGHTON UNIVERSITY · PI Hui Hong · 2021 to 2026
$16.1M
NIGMS NIH HHS P20 GM139762
6 · The paper itself

Abstract

Glioblastoma aggressively invades surrounding tissue by expressing matrix metalloproteinase-2 (MMP-2). Therefore, effective inhibition of MMP-2 is a desirable target for treatment. In some reports, the chlorotoxin (Ctx) polypeptide produced by the scorpion

Identifiers

PMID40791509
PMCPMC12338542

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.