Evidence map›Paper›PMID 40791495›Full record

ArticlebioRxiv : the preprint server for biology2025

Nuclear Hormone Receptor NHR-49/HNF4α Couples Fertility Regulation to Resource Allocation and Longevity in

Sharada Gopal, Amaresh Chaturbedi, Tej Ramachandrula, John OuYang, Rebecca Rodell, Siu Sylvia Lee

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sharada GopalDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA.ORCID 0009-0001-4421-6765
Amaresh ChaturbediDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA.ORCID 0000-0002-7599-8798
Tej RamachandrulaDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA.
John OuYangDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA.
Rebecca RodellDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA.
Siu Sylvia LeeDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA.ORCID 0000-0001-5225-4203

Funding

Systematic Analysis of C elegans Longevity DeterminantsR01AG024425 · NIA · CORNELL UNIVERSITY ITHACA · PI Siu Sylvia Lee · 2004 to 2026
$8.5M
Zeiss LSM710 Confocal Microscope for Shared Imaging FacilityS10RR025502 · NCRR · CORNELL UNIVERSITY · PI WILLIAMS, REBECCA M · 2009 to 2009
$500k
NCRR NIH HHS S10 RR025502NIA NIH HHS R01 AG024425
6 · The paper itself

Abstract

The nuclear hormone receptor NHR-49, a homolog of mammalian PPARα and HNF4α, is a key transcriptional regulator of nutrition sensing and fatty acid metabolism in

Indexed as

fatty acid metabolismNHR-49/HNF4α/PPARαnutrient sensingOocyte activationreproductive aging

Identifiers

PMID40791495
PMCPMC12338712

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.