Evidence map›Paper›PMID 40791491›Full record

ArticlebioRxiv : the preprint server for biology2025

The Left Insula Bridges Cognition, Emotion, and Brain Structure: A Multilayer Network Analysis of the Human Connectome Project-Young Adult.

Lyndon Firman-Sadler, Mervyn Singh, Juan F Domínguez D, Ivan L Simpson-Kent, Karen Caeyenberghs

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lyndon Firman-SadlerCognitive Neuroscience Unit, School of Psychology, Deakin University, Burwood VIC Australia.ORCID 0009-0003-0661-5743
Mervyn SinghCognitive Neuroscience Unit, School of Psychology, Deakin University, Burwood VIC Australia.ORCID 0000-0001-8058-3995
Juan F Domínguez DCognitive Neuroscience Unit, School of Psychology, Deakin University, Burwood VIC Australia.ORCID 0000-0002-6715-1060
Ivan L Simpson-KentDevelopmental and Educational Psychology Unit, Leiden University, Leiden, Netherlands.
Karen CaeyenberghsCognitive Neuroscience Unit, School of Psychology, Deakin University, Burwood VIC Australia.ORCID 0000-0001-7009-6843

Funding

Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
NIMH NIH HHS U54 MH091657
6 · The paper itself

Abstract

Multilayer network analyses allow for the exploration of complex relationships across different modalities. Specifically, this study employed a novel method that integrates psychometric networks with structural covariance networks to explore the relationships between cognition, emotion and the brain. Psychological (NIH Toolbox Cognition Battery and NIH Toolbox Emotion Battery) and anatomical MRI (cortical volume) data were extracted from the Human Connectome Project Young Adult dataset (

Identifiers

PMID40791491
PMCPMC12338507

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.